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Mouse Recombinant MIG (CXCL9)

Monokine induced by interferon-gamma

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Mouse Recombinant MIG (CXCL9)

Monokine induced by interferon-gamma

From: 91 USD
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Monokine induced by interferon-gamma
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Overview

Monokine induced by interferon-gamma (MIG), or CXCL9, is a member of the CXC chemokine family. MIG is closely related to two other chemokines: CXCL10 and CXCL11, all of which signal through the CXCR3 receptor (Ding et al.). MIG is secreted by a variety of immune cells including T cells, NK cells, dendritic cells, macrophages, and eosinophils, as well as non-immune cells including hepatic stellate cells, preadipocytes, thyrocytes, endothelial cells, tumor cells, fibroblasts, and glial cells of the central nervous system. MIG has also been shown to act as a chemoattractant for activated T cells and for tumor-infiltrating leukocytes (TILs), but not for neutrophils or for monocytes. MIG has also been reported to be both a tumor suppressor and tumor promoter in various types of cancer.
Subtype
Cytokines
Cell Type
Monocytes, T Cells
Species
Mouse
Area of Interest
Immunology
Purity
≥ 95%

Data Figures

(A) The biological activity of Mouse Recombinant MIG (CXCL9) was tested using a Ca2+ mobilization assay in CHO-K1 cells stably expressing Gα15 and CXCR3. Calcium mobilization was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which calcium mobilization is at 50% of maximum. The EC50 in the example above is less than 2 μg/mL. (B) 2 μg of Mouse Recombinant MIG (CXCL9) was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Mouse Recombinant MIG (CXCL9) has a predicted molecular mass of 12.3 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Mouse Recombinant MIG (CXCL9)
Catalog #
78177.1, 78177
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Mouse Recombinant MIG (CXCL9)
Catalog #
78177.1, 78177
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

Resources and Publications

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Quality Statement:

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.

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