Human/Mouse Recombinant GDF-11

Growth differentiation factor 11

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Human/Mouse Recombinant GDF-11

Growth differentiation factor 11

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Growth differentiation factor 11

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Overview

Growth differentiation factor 11 (GDF-11) is a member of transforming growth factor beta (TGF-β) family. It binds to the TGF-β receptors ALK4, ALK5, and ALK7 and activates the SMAD signaling pathway (Ho et al.). GDF-11 regulates the development of the olfactory system, retina, and pancreas, as well as anterior/posterior patterning of the axial skeleton (Lee & Lee). GDF-11 is an endocrine factor expressed in skeletal muscle, brain, and dental pulp (Kondás et al.). Studies in mice showed that GDF-11 regulates muscle and cardiac aging, and stimulates neurogenesis by remodeling blood vessels (Katsimpardi et al.; Loffredo et al.; Sinha et al.). This product is animal component-free.

Cytokines

Neural Cells, PSC-Derived

Human, Mouse

Neuroscience, Stem Cell Biology

≥ 95%

Data Figures

(A) The biological activity of Human/Mouse Recombinant GDF-11 was tested by its ability to inhibit alkaline phosphatase production in ATDC-5 cells. Inhibition of alkaline phosphatase production was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which alkaline phosphatase activity is at 50% of maximum. The EC50 in the above example is 2.63 ng/mL. (B) 1 μg of Human/Mouse Recombinant GDF-11 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type

Product Name

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Document Type

Product Information Sheet

Product Name

Human/Mouse Recombinant GDF-11

Catalog #

78110.1, 78110

Lot #

All

Language

English

Document Type

Safety Data Sheet

Product Name

Human/Mouse Recombinant GDF-11

Catalog #

78110.1, 78110

Lot #

All

Language

English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area

Workflow Stages

Workflow Stages for hPSC-Derived Neural Cell Research

Neural Induction

Expansion

Differentiation and Maturation

Characterization

Resources and Publications

Quality Statement:

PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.

Human/Mouse Recombinant GDF-11

Growth differentiation factor 11

Human/Mouse Recombinant GDF-11

Growth differentiation factor 11

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Overview

Data Figures

Protocols and Documentation

Applications

Resources and Publications

Educational Materials (4)

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