Human/Mouse Recombinant GDF-11

Growth differentiation factor 11

Human/Mouse Recombinant GDF-11

Growth differentiation factor 11

From: 189 USD
Catalog #
78110_C
Growth differentiation factor 11

Overview

Growth differentiation factor 11 (GDF-11) is a member of transforming growth factor beta (TGF-β) family. It binds to the TGF-β receptors ALK4, ALK5, and ALK7 and activates the SMAD signaling pathway (Ho et al.). GDF-11 regulates the development of the olfactory system, retina, and pancreas, as well as anterior/posterior patterning of the axial skeleton (Lee & Lee). GDF-11 is an endocrine factor expressed in skeletal muscle, brain, and dental pulp (Kondás et al.). Studies in mice showed that GDF-11 regulates muscle and cardiac aging, and stimulates neurogenesis by remodeling blood vessels (Katsimpardi et al.; Loffredo et al.; Sinha et al.). This product is animal component-free.
Subtype
Cytokines
Alternative Names
BMP-11, Bone morphogenetic protein 11, Growth differentiation factor 11
Cell Type
Neural Cells, PSC-Derived
Species
Human, Mouse
Area of Interest
Neuroscience, Stem Cell Biology
Molecular Weight
12.5 kDa monomer; 24.9 kDa dimer
Purity
≥ 95%

Data Figures

(A) The biological activity of Human/Mouse Recombinant GDF-11 was tested by its ability to inhibit alkaline phosphatase production in ATDC-5 cells. Inhibition of alkaline phosphatase production was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which alkaline phosphatase activity is at 50% of maximum. The EC50 in the above example is 2.63 ng/mL. (B) 1 μg of Human/Mouse Recombinant GDF-11 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
78110, 78110.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
78110, 78110.1
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

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