Human Recombinant RANTES (CCL5)

Regulated upon activation, normal T cell expressed and secreted
Catalog #
78099_C
Regulated upon activation, normal T cell expressed and secreted
From: 212 USD

Overview

RANTES (regulated upon activation, normal T cell expressed and secreted), also known as CCL5, is a member of the CC family of chemokines and is able to recruit leukocytes to sites of inflammation (Schall et al.). RANTES is secreted by T lymphocytes, macrophages, platelets, synovial fibroblasts, tubular epithelium, and certain types of tumor cells (Aldinucci & Colombatti; Soria & Ben-Baruch). This chemokine exerts its effect by interacting with the chemokine receptors CCR1, CCR3, CCR4, and CCR5. RANTES plays an active role in recruiting a variety of leukocytes into inflammatory sites, including T cells, macrophages, eosinophils, and basophils. In collaboration with certain cytokines that are released by T cells such as IL-2 and IFN-γ, RANTES also induces the activation and proliferation of NK cells to generate CC chemokine-activated killer cells, which are highly cytolytic (Lv et al.; Maghazachi et al.). It has been shown that RANTES produced by CD8+ T cells inhibits HIV infection of primary human peripheral blood mononuclear cells (Appay & Rowland-Jones; Cocchi et al.).
Subtype
Cytokines
Alternative Names
D17S136, Eosinophil chemotactic cytokine, Regulated upon activation normally T-expressed and secreted, SIS-delta, Small-inducible cytokine A5, T-cell specific protein p288
Cell Type
B Cells, Dendritic Cells, Mesenchymal Stem and Progenitor Cells, Monocytes, NK Cells, Other, T Cells, T Cells, CD4+, T Cells, CD8+
Species
Human
Area of Interest
Immunology, Stem Cell Biology
Molecular Weight
7.9 kDa
Purity
≥ 95%

Related Products

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Human Recombinant RANTES (CCL5)
Catalog #
78099, 78099.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant RANTES (CCL5)
Catalog #
78099, 78099.1
Lot #
All
Language
English

Educational Materials(3)

Brochure
Tools For Your Immunology Research
Brochure
Cytokines, Chemokines and Growth Factors
Wallchart
Human Immune Cytokines

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

(A) The biological activity of Human Recombinant RANTES (CCL5) was tested by its ability to induce chemotaxis of THP-1 cells. Cell migration was measured after 45 min using a fluorometric assay method. Increase in migration over basal level was seen starting at 10 ng/mL. (B) 1 μg of Human Recombinant RANTES (CCL5) was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant RANTES (CCL5) has a predicted molecular mass of 7.9 kDa.

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