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Session 5: Human Intestinal Organoids and Organ-on-a-Chip
Learning Objectives
After this session, you will be able to:
Understand the applications of human intestinal organoids for organ-on-a-chip platforms
Estimated time for completion: 30 minutes
Instructor Bios
Dr. Hossein Eslami Amirabadi, Co-founder & CEO, AZAR Innovations
Hossein is the founder of AZAR Innovations. Working with organs-on-chips since 2013, his passion is to enable the use of complex in vitro models for biomedical research. He received his PhD in Biomedical/Mechanical Engineering in 2018 in the group of Prof. Jaap den Toonder at Eindhoven University of Technology. He then joined the Netherlands Organisation for Applied Scientific Research (TNO) in collaboration with the Department of Pharmaceutical Sciences at Utrecht University to develop intestine, intestine-microbiome, and multi-organ-on-a-chip models for pharmaceutical applications. He is an inventor of three patents related to organs-on-a-chips. Seeing a gap between different disciplines, Hossein founded AZAR Innovations in 2021 intending to make organ-on-a-chip systems available for everyone. He has developed together with biologists organs-on-chips for many different applications, from the osteochondral interface to metastasis of prostate circulating cells to bone. He is currently a member of the board of directors at 3Rs Collaborative.
Emre is a co-founder of AZAR Innovations and a researcher passionate about implementing advanced research models to study human (patho)physiology in vitro. During his PhD, he used pluripotent stem cell-derived organoids and adult progenitor/stem cell-derived tubuloids to mimic and understand the kidney in vitro. In addition, he is exploring how combining these organoid models with organ-on-a-chip models can provide the optimal research tools to increase translational value. With 5 years of organoid and organ-on-a-chip experience, he brings valuable biological insights into AZAR Innovations.
Lecture 5 Part 1: Introduction to AZAR Innovations