Human Recombinant IGF-I

Insulin-like growth factor 1

Human Recombinant IGF-I

Insulin-like growth factor 1

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Insulin-like growth factor 1
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Overview

Insulin-like growth factor 1 (IGF-I) is a polypeptide that belongs to the family of insulin-like growth factors that are similar in molecular structure to proinsulin. IGF-I binds to the IGF-I receptor and is a potent activator of the PI3K/AKT pathway and also activates ERK1/2 signaling. IGF-I is required for embryonic development, and it is produced mainly in the liver in response to a hepatocyte growth hormone. In the absence of insulin, IGF-I is necessary for the maintenance of human pluripotent stem cells (Wang et al.). Together with IL-3, IGF-I stimulates differentiation and proliferation of myeloid cells and has been shown to regulate lymphopoiesis by stimulating proliferation and differentiation of T and B cells in lymphoid organs (Heemskerk et al.).
Subtype
Cytokines, Growth Factors
Cell Type
Neural Cells, PSC-Derived, Neural Stem and Progenitor Cells, Prostate Cells
Species
Human
Area of Interest
Epithelial Cell Biology, Neuroscience, Stem Cell Biology
Purity
≥ 95%

Data Figures

(A) The biological activity of Human Recombinant IGF-I was tested by its ability to promote the proliferation of FDC-P1 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is less than 5 ng/mL.
(B) 2 μg of Human Recombinant IGF-I was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IGF-I has a predicted molecular mass of 7.7 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
78022.2, 78022, 78022.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
78022.2, 78022, 78022.1
Lot #
All
Language
English

Resources and Publications

Educational Materials (1)