BrainPhys™ Neuronal Medium is a new, defined and serum-free neuronal basal medium for the culture of primary neurons and the generation and maturation of human pluripotent stem cell (hPSC)-derived neurons. Based on the formulation invented by Dr. Cedric Bardy and Dr. Fred H. Gage (C Bardy et al. Proc Natl Acad Sci USA, 2015), BrainPhys™ Neuronal Medium is more representative of the brain's extracellular environment and increases the proportion of synaptically active neurons. Using BrainPhys™ Neuronal Medium increases the physiological relevance of in vitro neuroscience research and improves the probability of successful translation of scientific discoveries from the laboratory to the clinic.
Why Use BrainPhys™ Neuronal Medium?
More representative of the brain’s extracellular environment.
Improved neuronal function and a higher proportion of synaptically active neurons.
Perform functional assays without replacing media.
Supports long-term culture of primary and ES/iPS cell-derived neurons.
Rigorous raw material screening and quality control ensure minimal lot-to-lot variability.
Our goal was to develop a culture condition that would support both healthy neuronal circuits and let us monitor the functional properties of mature neurons, without having to switch to different media. Specifically, we reasoned that such cell media should allow for optimal physiological neuronal activity. After sharing our work with our colleagues, we wanted to make this neuronal medium easily available to the scientific community.
Dr. Cedric Bardy
Salk Institute for Biological Studies
Quote from the press release