Anti-Human CD25 Antibody, Clone 2A3

Mouse monoclonal IgG1 antibody against human, cynomolgus CD25

Anti-Human CD25 Antibody, Clone 2A3

Mouse monoclonal IgG1 antibody against human, cynomolgus CD25

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Mouse monoclonal IgG1 antibody against human, cynomolgus CD25
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Overview

The 2A3 antibody reacts with human CD25, a 55 kDa type I integral transmembrane glycoprotein also known as low-affinity interleukin 2 receptor alpha chain (IL-2Rα) or Tac antigen. CD25 is present on activated T and B cells, monocytes, macrophages, and regulatory T cells. CD25 has a role in T lymphocyte activation and can be used in the identification of T cell subsets in viral infections like HIV and HTLV. CD25 associates with IL-2 receptor β (CD122) and common γ (CD132) chains to form a high-affinity IL-2R complex. The 2A3 antibody binds to an epitope on p55 at or near the IL-2 binding site and prevents high-affinity IL-2 binding to T lymphocytes. Daclizumab, a therapeutic humanized monoclonal antibody, blocks the binding of 2A3 antibody.
Subtype
Primary Antibodies
Target Antigen
CD25
Reactive Species
Cynomolgus, Human
Conjugation
PE
Host Species
Mouse
Cell Type
T Cells, T Cells, Regulatory
Species
Human
Application
Cell Isolation, Flow Cytometry
Area of Interest
Immunology, Cell Therapy Development

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
60153PE
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
60153PE
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Resources and Publications