"Merging Stem Cells with Immunology" Featuring Dr. Filipe Pereira
On this episode of the Immunology Podcast, Dr. Filipe Pereira discusses the interdisciplinary approach his lab takes to mechanistically understand hematopoietic and immune cell identities.
Dr. Filipe Pereira is an Associate Professor at the Lund Stem Cell Center at Lund University. The Pereira lab studies how hematopoietic cell fate is specified, maintained, and eventually modified or reversed. Inspired by the fields of stem cell biology, immunology, and cancer, they use an interdisciplinary approach to mechanistically understand hematopoietic and immune cell identities and translate their findings into novel gene and cell therapies.
I was very intrigued by the potential clinical applications of Dr. Pereira’s work; particularly the potential it offers in the field of immune-oncology and the ability to engage cell-specific cancer antigens without having pre-knowledge of them.
Dr. Jason Goldsmith, host
Find more episodes at immunologypodcast.com or wherever you get your podcasts.
This Episode's Stem Cell Roundup:
- Resident T Cells Stay at Home – Researchers examined how immunity is integrated within adult mouse tissues and observed durable maintenance of resident memory T cells up to 450 days after infection.
- Bacteria-Derived Peptides Found Inside Tumors – Scientists identified a peptide repertoire derived from intracellular bacteria that was presented on HLA-I and HLA-II molecules in melanoma tumors.
- Gamma Delta T Cells Link Immunity to Nutrition – Researchers analyzed mice fed a high-carbohydrate versus a high-protein diet and observed remodeling of the small intestinal epithelium in response to dietary carbohydrates.
- Neutrophil Extracellular Traps (NETs) Activate Innate Immune Sensor – In mice, NETs stimulated interferon production in a cGAS-dependent manner, suggesting that cGAS acts as a sensor of NETs to stimulate immune responses during infection.
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