"T Cell Regulation" Featuring Dr. Dario Vignali

On this episode of the Immunology Podcast, Dr. Dario Vignali discusses T cell regulation and the new mouse model that his lab recently generated to target conventional CD4 T cells.

Dr. Dario Vignali is the Frank Dixon Chair in Cancer Immunology and Vice Chair and Professor of Immunology at the University of Pittsburgh School of Medicine. His lab studies various aspects of T cell regulation, and recently generated a new mouse model to target conventional CD4 T cells.

Regulating the regulators, mouse models for conventional CD4 T cells, and the importance of staying positive (and brewing some beer!) to get over the tough times. Our conversation with Dr. Vignali has it all!

Dr. Brenda Raud, host

Find more episodes at immunologypodcast.com or wherever you get your podcasts.

This Episode's Immunology Roundup:

  • Dual Targeting for B Cell Leukemia – CAR T therapy targeting both CD19 and CD22 showed clinical activity and low toxicity in a Phase I trial, but strategies to further improve CAR T cell persistence are needed.
  • Microbial Fitness in the Intestine – Researchers showed that microbial exposure leads to the selection of antigen-specific intestinal plasma cells with a diverse Ig gene repertoire.
  • Less Is More for COVID-19 Vaccine Dosage – A 1000-fold lower prime dose of an adenovirus-based SARS-CoV-2 vaccine followed by a standard boost dose elicited superior immune responses compared to two standard doses.
  • IL-33 in Inflammation Resolution – IL-33 induces metabolic reprogramming, which controls the differentiation of alternatively activated macrophages that contribute to the resolution of inflammation and tissue repair.
Publish Date: March 17, 2022

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