SARS-CoV-2 Recombinant Spike Protein, aa16-685 (HEK293-expressed)

SARS-CoV-2 recombinant spike protein, amino acids Val16-Arg685, FLAG & His tags

SARS-CoV-2 Recombinant Spike Protein, aa16-685 (HEK293-expressed)

SARS-CoV-2 recombinant spike protein, amino acids Val16-Arg685, FLAG & His tags

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SARS-CoV-2 recombinant spike protein, amino acids Val16-Arg685, FLAG & His tags
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Overview

SARS-CoV-2 Recombinant Spike Protein, aa16-685 is expressed in HEK293 cells and is one of four structural proteins encoded by the SARS-CoV-2 genome. The Spike Protein plays a key role in attachment to host cells, allowing invasion through clathrin-mediated endocytosis. The Spike Protein can be cleaved by host cell proteases after aa685 to yield the N-terminal S1 subunit and C-terminal S2 region. The S1 subunit is responsible for interacting with the host cell receptor (angiotensin-converting enzyme II) through a receptor-binding domain that is highly conserved with SARS-CoV. The S1 subunit has two conformations: a ‘down’ conformation in which the receptor is inaccessible, and an ‘up’ conformation in which the receptor is accessible. These conformational changes are key for monoclonal antibody drugs and vaccine development. SARS-CoV-2 Recombinant Spike Protein contains a polyhistidine tag at the amino terminus; it also contains a FLAG tag at the carboxy terminus.
Subtype
Recombinant Proteins
Alternative Names
S protein, Spike glycoprotein
Cell Type
B Cells, Lymphocytes, Plasma, T Cells, T Cells, CD4+, T Cells, CD8+
Species
Human
Area of Interest
Infectious Diseases
Purity
≥ 85%

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
100-0594, 100-0595
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
100-0594, 100-0595
Lot #
All
Language
English