Recombinant B18R Protein

B18R protein
Catalog #
78075_C
B18R protein
From: 736 EUR

Overview

The B18R protein, which is encoded by the B18R open reading frame in the Western Reserve (WR) strain of vaccinia virus, is a type I interferon (IFN)-binding protein that is known to inhibit IFN antiviral response (Colamonici et al.). B18R protein has been shown to exhibit neutralizing activity to type I interferon family members (Meyers et al.) and to protect cells from the antiviral effects of interferon (Vancová et al.). It was recently shown that HIV-1–dependent induction of type I IFN activity and BAFF protein levels was abrogated by the soluble B18R protein, with no effect observed on the cell viability (Gomez et al.). B18R protein has been reported to aid in cellular reprogramming using RNA-mediated gene delivery (Warren et al.; Yoshioka N et al.).
Subtype
Cytokines
Alternative Names
Type I IFN inhibitor, Vaccinia virus-encoded neutralizing type I interferon receptor
Cell Type
Pluripotent Stem Cells
Species
Human
Area of Interest
Stem Cell Biology
Molecular Weight
38.4 kDa
Purity
≥ 98%

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Recombinant B18R Protein
Catalog #
78075, 78075.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Recombinant B18R Protein
Catalog #
78075, 78075.1
Lot #
All
Language
English

Educational Materials (1)

Brochure
Cytokines, Chemokines and Growth Factors

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