SARS-CoV-2 Recombinant Spike Protein, aa319-541 (Yeast-expressed)

SARS-CoV-2 recombinant spike protein, amino acids Arg319-Phe541, His tag

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SARS-CoV-2 Recombinant Spike Protein, aa319-541 (Yeast-expressed)

SARS-CoV-2 recombinant spike protein, amino acids Arg319-Phe541, His tag

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SARS-CoV-2 recombinant spike protein, amino acids Arg319-Phe541, His tag

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Overview

SARS-CoV-2 Recombinant Spike Protein, aa319-541 is expressed in Pichia pastoris and is one of four structural proteins encoded by the SARS-CoV-2 genome. The Spike Protein plays a key role in attachment to host cells allowing invasion through clathrin-mediated endocytosis. The Spike Protein can be cleaved by host cell proteases after aa685 to yield the N-terminal S1 subunit, and C-terminal S2 region. The S1 subunit is responsible for interacting with the host cell receptor (angiotensin-converting enzyme II) through a receptor-binding domain that is highly conserved with SARS-CoV. The S1 subunit has two conformations: a ‘down’ conformation in which the receptor is inaccessible, and an ‘up’ conformation in which the receptor is accessible. These conformational changes are key for monoclonal antibody drugs and vaccine development. At the amino terminus of the polypeptide chain, SARS-CoV-2 Recombinant Spike Protein contains a polyhistidine tag and a SUMOstar site.

Recombinant Proteins

S protein, Spike glycoprotein

B Cells, Lymphocytes, Plasma, T Cells, T Cells, CD4+, T Cells, CD8+

Human

Infectious Diseases

≥ 90%

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

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Product Information Sheet

Product Name

SARS-CoV-2 Recombinant Spike Protein, aa319-541 (Yeast-expressed)

Catalog #

100-0596, 100-0597

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All

Language

English

Document Type

Safety Data Sheet

Product Name

SARS-CoV-2 Recombinant Spike Protein, aa319-541 (Yeast-expressed)

Catalog #

100-0596, 100-0597

Lot #

All

Language

English

Resources and Publications

Related Products

Quality Statement:

PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.

SARS-CoV-2 Recombinant Spike Protein, aa319-541 (Yeast-expressed)

SARS-CoV-2 recombinant spike protein, amino acids Arg319-Phe541, His tag

SARS-CoV-2 Recombinant Spike Protein, aa319-541 (Yeast-expressed)

SARS-CoV-2 recombinant spike protein, amino acids Arg319-Phe541, His tag

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Overview

Protocols and Documentation

Resources and Publications

Educational Materials (6)

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