SARS-CoV-2 Recombinant Spike Protein, aa319-541 (Yeast-expressed)

SARS-CoV-2 recombinant spike protein, amino acids Arg319-Phe541, His tag
Catalog #
100-0596_C
SARS-CoV-2 recombinant spike protein, amino acids Arg319-Phe541, His tag
From: 630 USD

Overview

SARS-CoV-2 Recombinant Spike Protein, aa319-541 is expressed in Pichia pastoris and is one of four structural proteins encoded by the SARS-CoV-2 genome. The Spike Protein plays a key role in attachment to host cells allowing invasion through clathrin-mediated endocytosis. The Spike Protein can be cleaved by host cell proteases after aa685 to yield the N-terminal S1 subunit, and C-terminal S2 region. The S1 subunit is responsible for interacting with the host cell receptor (angiotensin-converting enzyme II) through a receptor-binding domain that is highly conserved with SARS-CoV. The S1 subunit has two conformations: a ‘down’ conformation in which the receptor is inaccessible, and an ‘up’ conformation in which the receptor is accessible. These conformational changes are key for monoclonal antibody drugs and vaccine development. At the amino terminus of the polypeptide chain, SARS-CoV-2 Recombinant Spike Protein contains a polyhistidine tag and a SUMOstar site.
Subtype
Recombinant Proteins
Alternative Names
S protein; Spike glycoprotein
Area of Interest
Infectious Diseases
Molecular Weight
38.1 kDa
Purity
≥ 90%

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
SARS-CoV-2 Recombinant Spike Protein, aa319-541 (Yeast-expressed)
Catalog #
100-0596, 100-0597
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
SARS-CoV-2 Recombinant Spike Protein, aa319-541 (Yeast-expressed)
Catalog #
100-0596, 100-0597
Lot #
All
Language
English

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