SARS-CoV-2 Recombinant Spike Protein, aa16-685 (HEK293-expressed)

SARS-CoV-2 recombinant spike protein, amino acids Val16-Arg685, FLAG & His tags

SARS-CoV-2 Recombinant Spike Protein, aa16-685 (HEK293-expressed)

SARS-CoV-2 recombinant spike protein, amino acids Val16-Arg685, FLAG & His tags

From: 1,088 USD
Catalog #
100-0594_C
SARS-CoV-2 recombinant spike protein, amino acids Val16-Arg685, FLAG & His tags

Overview

SARS-CoV-2 Recombinant Spike Protein, aa16-685 is expressed in HEK293 cells and is one of four structural proteins encoded by the SARS-CoV-2 genome. The Spike Protein plays a key role in attachment to host cells, allowing invasion through clathrin-mediated endocytosis. The Spike Protein can be cleaved by host cell proteases after aa685 to yield the N-terminal S1 subunit and C-terminal S2 region. The S1 subunit is responsible for interacting with the host cell receptor (angiotensin-converting enzyme II) through a receptor-binding domain that is highly conserved with SARS-CoV. The S1 subunit has two conformations: a ‘down’ conformation in which the receptor is inaccessible, and an ‘up’ conformation in which the receptor is accessible. These conformational changes are key for monoclonal antibody drugs and vaccine development. SARS-CoV-2 Recombinant Spike Protein contains a polyhistidine tag at the amino terminus; it also contains a FLAG tag at the carboxy terminus.
Subtype
Recombinant Proteins
Alternative Names
S protein; Spike glycoprotein
Cell Type
B Cells, Lymphocytes, Plasma, T Cells, T Cells, CD4+, T Cells, CD8+
Species
Human
Area of Interest
Infectious Diseases
Molecular Weight
79.5 kDa
Purity
≥ 85%

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
100-0594, 100-0595
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
100-0594, 100-0595
Lot #
All
Language
English

Contact STEMCELL Technologies

Our Customer Service, Sales, and Product and Scientific Support departments in North America are available between 6 am and 5 pm Pacific Time (9 am and 8 pm Eastern Time). One of our representatives will be happy to help you by telephone or email. Please complete the form to contact us by email. A representative will get back to you shortly.
  •  

StemCell Technologies Inc. and affiliates ("STEMCELL Technologies") does not share your email address with third parties. StemCell Technologies Inc. will use your email address to confirm your identity and send you newsletters, transaction-related emails, promotional and customer service emails in accordance with our privacy policy. You can change your email preferences at any time.