SARS-CoV-2 Recombinant Spike Protein, aa16-685 (HEK293-expressed)
SARS-CoV-2 recombinant spike protein, amino acids Val16-Arg685, FLAG & His tags
Overview
SARS-CoV-2 Recombinant Spike Protein, aa16-685 is expressed in HEK293 cells and is one of four structural proteins encoded by the SARS-CoV-2 genome. The Spike Protein plays a key role in attachment to host cells, allowing invasion through clathrin-mediated endocytosis. The Spike Protein can be cleaved by host cell proteases after aa685 to yield the N-terminal S1 subunit and C-terminal S2 region. The S1 subunit is responsible for interacting with the host cell receptor (angiotensin-converting enzyme II) through a receptor-binding domain that is highly conserved with SARS-CoV. The S1 subunit has two conformations: a ‘down’ conformation in which the receptor is inaccessible, and an ‘up’ conformation in which the receptor is accessible. These conformational changes are key for monoclonal antibody drugs and vaccine development. SARS-CoV-2 Recombinant Spike Protein contains a polyhistidine tag at the amino terminus; it also contains a FLAG tag at the carboxy terminus.
Subtype
Recombinant Proteins
Alternative Names
S protein; Spike glycoprotein
Area of Interest
Infectious Diseases
Molecular Weight
79.5 kDa
Purity
≥ 85%
Related Products
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Scientific Resources
Product Documentation
| Document Type | Product Name | Catalog # | Lot # | Language |
|---|---|---|---|---|
|
Document Type
Product Information Sheet
|
Product Name
SARS-CoV-2 Recombinant Spike Protein, aa16-685 (HEK293-expressed)
|
Catalog #
100-0594, 100-0595 |
Lot #
All |
Language
English |
|
Document Type
Safety Data Sheet
|
Product Name
SARS-CoV-2 Recombinant Spike Protein, aa16-685 (HEK293-expressed)
|
Catalog #
100-0594, 100-0595 |
Lot #
All |
Language
English |
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