Mouse Recombinant RANKL, ACF

Receptor activator of nuclear factor kappa-Β ligand, animal component-free
Catalog #
100-0943_C
Receptor activator of nuclear factor kappa-Β ligand, animal component-free
From: 985 USD

Overview

Receptor activator of nuclear factor kappa-B ligand (RANKL) is a member of the tumor necrosis factor (TNF) superfamily (Anderson et al.). Cytokines in the TNF superfamily are involved in a variety of long-term cellular activities such as differentiation, proliferation, and cell death (MacEwan). RANKL is a type II homotrimeric transmembrane protein expressed in both a membrane-bound and secreted form (Ikeda et al.). RANKL binds to the receptor activator of nuclear factor kappa-B (RANK). Upon binding to its receptor, RANKL activates the AKT signaling pathway (Moon et al.). Osteoprotegerin (OPG) may also bind RANKL, and this binding competes with RANKL-RANK binding (Lacey et al.). RANKL is involved in osteoclastogenesis (Lacey et al.; Yasuda et al.) and T cell activation (Wong et al.). This product is animal component-free.
Alternative Names
CD254, hRANKL2, ODF, OPGL, OPTB2, Osteoclast differentiation factor, soluble Receptor activator of NF-κB ligand, sOdf, TNF-related activation-induced cytokine, TNFSF11, TNF superfamily member 11, TNLG6B, Tumor necrosis factor superfamily member 11, TRAN
Species
Mouse
Area of Interest
Cancer, Immunology
Molecular Weight
19.5 kDa
Purity
≥ 95%

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Mouse Recombinant RANKL, ACF
Catalog #
100-0943
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Mouse Recombinant RANKL, ACF
Catalog #
100-0943
Lot #
All
Language
English

Educational Materials (2)

Brochure
Tools For Your Immunology Research
Brochure
Cytokines, Chemokines and Growth Factors

Data and Publications

Data

Figure 1.

(A) The activity of Mouse Recombinant RANKL, ACF was tested by its ability to activate RAW-BlueTM cells. The EC50 is defined as the effective concentration of the growth factor at which binding is at 50% of maximum. The EC50 in the above example is 11.3 ng/mL. (B) Mouse Recombinant RANKL, ACF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Mouse Recombinant RANKL, ACF has a predicted molecular mass of 19.5 kDa (monomer).

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