Human Recombinant R-Spondin-3

R-Spondin-3, His tag
Human Recombinant R-Spondin-3

R-Spondin-3, His tag

50 µg
Catalog # 100-0934
479 USD

Overview

R-Spondin-3 is a member of thrombospondin type 1 repeat (TSR-1) superfamily that is involved in the canonical Wnt/β-catenin signaling pathway (de Lau et al.). R-spondin proteins are characterized by two furin-like repeats at the amino terminus and thrombospondin domain located near the carboxyl terminus (de Lau et al.). R-spondin-3 expression is associated with ovarian cancer (Gu et al.), prostate cancer (Mesci et al.), and differentiation of intestinal epithelial cells in diabetes mellitus (Shan et al.). In a transgenic mice model, the expression of R-Spondin-3 induces the expansion of Lgr5+ stem cells, Paneth cells, and Lgr4+ cells, promoting the intestinal stem cell compartment (Hilkens et al.). This protein contains a His-residue tag at the carboxyl end of the polypeptide chain.
Alternative Names
Cristin 1, hRspo3, PWTSR, R-Spondin 3, Roof plate-specific spondin-3, RSPO3, RSpondin 3, Thrombospondin type-1 domain-containing protein 2, THSD2
Species
Human
Area of Interest
Organoids, Stem Cell Biology
Molecular Weight
15.3 kDa
Purity
≥ 93%

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Human Recombinant R-Spondin-3
Catalog #
100-0934
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant R-Spondin-3
Catalog #
100-0934
Lot #
All
Language
English

Educational Materials (2)

Brochure
Products for Human Pluripotent Stem Cells
Brochure
Cytokines, Chemokines and Growth Factors

Data and Publications

Data

Figure 1.

(A) The binding activity of Human Recombinant R-Spondin-3 was tested by functional ELISA with immobilized Human Recombinant R-Spondin-3 at 2000 ng/mL. Immobilized Human Recombinant R-Spondin-3 can bind human RNF43 hFc with a linear range of 3 - 12 ng/mL. (B) Human Recombinant R-Spondin-3 was resolved with SDS-PAGE under reducing (+) conditions and visualized by Coomassie Blue staining. Human Recombinant R-Spondin-3 has a predicted molecular mass of 15.3 kDa, but the apparent molecular mass is approximately 22 kDa to 27 kDa due to different glycosylation.

Contact STEMCELL Technologies

Our Customer Service, Sales, and Product and Scientific Support departments in North America are available between 6 am and 5 pm Pacific Time (9 am and 8 pm Eastern Time). One of our representatives will be happy to help you by telephone or email. Please complete the form to contact us by email. A representative will get back to you shortly.
  •  

StemCell Technologies Inc. and affiliates ("STEMCELL Technologies") does not share your email address with third parties. StemCell Technologies Inc. will use your email address to confirm your identity and send you newsletters, transaction-related emails, promotional and customer service emails in accordance with our privacy policy. You can change your email preferences at any time.