Human Recombinant IL-34

Interleukin 34, His tag
Catalog #
100-0930_C
Interleukin 34, His tag
From: 999 USD

Overview

Interleukin 34 (IL-34) is well known for its ability to induce the formation of colony-forming unit macrophages in human bone marrow cell cultures (Foucher et al.; Wei et al.). This dimeric glycoprotein is a member of the short-chain helical hematopoietic cytokine family (Baghdadi et al.; Foucher et al.), and exists in two isoforms that differ by a single glutamine (Chen et al.; Foucher et al; Wei et al.). IL-34 interacts with M-CSF to trigger tyrosine phosphorylation of the receptor and ERK1/2 pathways. (Wang et al.; Wei et al.). It is expressed in many tissues (heart, brain, lung, liver, kidney, thymus, testes, ovary, small intestine, prostate, and colon), with the highest expression in the spleen. In combination with RANKL (Catalog #78214), IL-34 induces osteoclast differentiation (Chen et al.; Foucher et al.). IL-34 expression is decreased in Alzheimer’s disease and atopic dermatitis, while high levels of IL-34 are found in many types of cancer correlated with poor prognosis, chronic heart failure or coronary artery disease, inflammatory bowel disease, influenza A infection, during acute liver transplant rejection or in non-alcoholic fatty liver disease, and with rheumatoid arthritis (Baghdadi et al.). It is therefore a possible pharmacological target for treating bone or inflammatory diseases (Chen et al.). This protein contains a His-residue tag at the carboxyl end of the polypeptide chain, and the protein was purified as a homodimer consisting of 39 kDa monomers (Lin et al.).
Alternative Names
C16orf77, IL-34, IL34, Interleukin 34
Species
Human
Area of Interest
Immunology, Infectious Diseases
Molecular Weight
26.7 kDa
Purity
≥ 92%

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Human Recombinant IL-34
Catalog #
100-0930
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant IL-34
Catalog #
100-0930
Lot #
All
Language
English

Educational Materials (2)

Brochure
Tools For Your Immunology Research
Brochure
Cytokines, Chemokines and Growth Factors

Data and Publications

Data

Figure 1.

(A) The biological activity of Human Recombinant IL-34 was tested by its ability to promote the proliferation of human PBMCs. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 2 - 8 ng/mL. (B) Human Recombinant IL-34 was resolved with SDS-PAGE under reducing (+) conditions and visualized by Coomassie Blue staining. Human Recombinant IL-34 has a predicted molecular mass of 39 kDa (Lin et al).

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