Anti-Human CD4 Antibody, Clone SK3

Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD4

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From: 42 USD

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Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD4
From: 42 USD

Overview

The SK3 antibody reacts with CD4, an ~59 kDa single-chain type 1 transmembrane glycoprotein and member of the immunoglobulin (Ig) superfamily; CD4 contains four extracellular Ig-like domains (D1 - D4). The epitope for SK3 has been localized to the D3 domain of the protein, which has a structure resembling an Ig variable domain. CD4 is expressed at relatively high levels by most thymocytes and a subpopulation of T cells (T-helper cells), and at lower levels by peripheral blood monocytes and macrophages. CD4 binds to a nonpolymorphic region of MHC II and acts as a co-receptor to the T cell receptor (TCR) in MHC II-restricted antigen recognition by enhancing the affinity of the association between the TCR and MHC II-antigen complex. CD4 also functions to amplify signals from the TCR to the cytoplasm through the interaction of its intracellular domain with cytoplasmic tyrosine kinases such as Lck. Moreover, CD4 is a receptor for the human immunodeficiency virus (HIV). Binding of the SK3 antibody blocks HIV binding and mixed lymphocyte reaction (MLR).
Subtype:
Primary Antibodies
Target Antigen:
CD4; CD5
Reactive Species:
Human
Conjugation:
PE
Host Species:
Mouse
Cell Type:
T Cells, Regulatory; T Cells; T Cells, CD4+
Application:
Cell Isolation; Flow Cytometry
Area of Interest:
Immunology

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(3)

Data and Publications

Data

FACS Profile Results With RosetteSep™ Human Cord Blood Progenitor CellEnrichment Kit

Figure 1. Data for PE Conjugated

Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD4 Antibody, Clone SK3, PE (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, PE (Catalog #60070PE; solid line histogram).

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.