Anti-Human ACE2 Antibody, Clone AC384

Mouse monoclonal IgG1 antibody against human angiotensin-converting enzyme 2 (ACE2)
Catalog #
100-0759_C
Mouse monoclonal IgG1 antibody against human angiotensin-converting enzyme 2 (ACE2)
From: 269 EUR

Overview

The AC384 antibody reacts with angiotensin-converting enzyme 2 (ACE2), a type I integral membrane protein, which includes a short C-terminal cytoplasmic domain made of 22 amino acids, a transmembrane domain, and a large N-terminal ectodomain made of 740 amino acids. The N-terminal domain of ACE2 contains a catalytic zinc-binding motif, which shares a 42% similarity to the catalytic binding domain of ACE. Despite the similarity in catalytic domains, ACE2 functions as a carboxypeptidase, while ACE functions as either a peptidyl dipeptidase or an endopeptidase. In humans, ACE2 is a key regulator of the renin-angiotensin system, where it catalyzes the cleavage of the vasoconstrictor peptide angiotensin II to angiotensin 1-7. Expression of ACE2 can be found on endothelial cells throughout the body, such as in the kidney, heart, and lungs. In the airways leading to the lungs, ACE2 provides the main entry point for SARS-CoV-2 (2019-nCoV). Once the SARS-CoV-2 Spike Protein binds to ACE2, viral fusion with the host cell membrane can occur, resulting in viral RNA genome delivery.
Target Antigen
Angiotensin-Converting Enzyme 2
Alternative Names
SARS Receptor, Angiotensin-converting Enzyme 2, ACEH, Metalloprotease MPROT15, SARS-CoV-2 Receptor
Reactive Species
Human
Conjugation
Biotin, Unconjugated
Host Species
Mouse
Cell Type
Airway Cells, Epithelial Cells
Application
ELISA, Flow Cytometry, Neutralization and Blocking, Western Blotting
Area of Interest
Disease Modeling, Epithelial Cell Biology, Respiratory Research
Clone
AC384
Gene ID
59272
Isotype
IgG1, kappa

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Anti-Human ACE2 Antibody, Clone AC384
Catalog #
100-0759, 100-0760
Lot #
All
Language
English
Document Type
Product Information Sheet
Product Name
Anti-Human ACE2 Antibody, Clone AC384, Biotin
Catalog #
100-0761
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human ACE2 Antibody, Clone AC384
Catalog #
100-0759, 100-0760
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human ACE2 Antibody, Clone AC384, Biotin
Catalog #
100-0761
Lot #
All
Language
English

Educational Materials (6)

Brochure
Reliable Antibodies for Your Research
Brochure
PneumaCult™ Culture Media for Human Airway Epithelial Cells
Protocol
How to Perform Immunocytochemistry (ICC) Staining of Epithelial Cells Cultured as Monolayers or at the Air-Liquid Interface
Wallchart
SnapShot: COVID-19
Webinar
Studying Respiratory Viruses with ALI Cultures
6:56
Studying Respiratory Viruses with ALI Cultures
Mini Review
Airway Epithelial Cells of the Human Respiratory System

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

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