Mouse Recombinant IL-5

Interleukin 5

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Mouse Recombinant IL-5

Interleukin 5

From: 204 USD

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100 µg 25 µg

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Interleukin 5

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Overview

Interleukin 5 (IL-5) is a member of the short-chain 4-α-helical bundle subset of hematopoietic cytokines. It binds to the specific α receptor, which in turn recruits the common β receptor that initiates signaling via JAK/STAT and MAPK pathways. IL-5 is produced by Th2 cells, eosinophils, activated mast cells, and ILC2 cells. IL-5 affects the differentiation, activation, and survival of eosinophils, thus playing an important role in allergic inflammation, asthma, and parasite immunity. Stimulation of eosinophils with IL-5 leads to their activation, upregulation of CD11b expression, and inhibition of apoptosis (Shearer).

Cytokines

B Cells, Granulocytes and Subsets, Hematopoietic Stem and Progenitor Cells

Mouse

Immunology, Stem Cell Biology

≥ 95%

Data Figures

(A) The biological activity of Mouse Recombinant IL-5 was tested by its ability to promote the proliferation of TF-1 cells. Cell proliferation was measured after 70 hours of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 0.15 - 0.22 ng/mL.
(B) 1 μg of Mouse Recombinant IL-5 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Mouse Recombinant IL-5 has a predicted molecular mass of 26.3 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type

Product Name

Catalog #

Lot #

Language

Document Type

Product Information Sheet

Product Name

Mouse Recombinant IL-5

Catalog #

78049.1, 78049

Lot #

All

Language

English

Document Type

Safety Data Sheet

Product Name

Mouse Recombinant IL-5

Catalog #

78049.1, 78049

Lot #

All

Language

English

Resources and Publications

Related Products

Quality Statement:

PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.

Mouse Recombinant IL-5

Interleukin 5

Mouse Recombinant IL-5

Interleukin 5

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Overview

Data Figures

Protocols and Documentation

Resources and Publications

Educational Materials (3)

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