Anti-Mouse CD54 (ICAM-1) Antibody, Clone YN1/1.7.4
Rat monoclonal IgG2b antibody against mouse CD54
Overview
The YN1/1.7.4 antibody reacts with CD54, a 90 - 110 kDa type I transmembrane glycoprotein that is a member of the immunoglobulin (Ig) superfamily. CD54 consists of five Ig-like C2 type domains and has two isoforms generated from alternative splicing. As an important intercellular adhesion molecule, CD54 is involved in inflammatory reactions, antigen-specific immune responses, lymphocyte trafficking, and T cell signal transduction events. CD54 mediates important cell-cell interactions and adhesion reactions by binding to its major ligands, LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). CD54 may also act as a receptor for rhinoviruses and some coxsackieviruses. CD54 is expressed on lymphocytes, monocytes, macrophages, dendritic cells, endothelial cells, and high endothelial venules. Expression of CD54 is upregulated on activated lymphocytes and also, following stimulation with inflammatory mediators such as cytokines, LPS, and IFN-γ.
Subtype
Primary Antibodies
Target Antigen
CD54 (ICAM-1)
Alternative Names
BB2, Cell surface glycoprotein P3.58, Human rhinovirus receptor, Intercellular adhesion molecule 1, Ly-47, MALA2, MyD10
Reactive Species
Mouse
Conjugation
Unconjugated
Host Species
Rat
Cell Type
Endothelial Cells
Species
Mouse
Application
Cell Isolation, Flow Cytometry, Immunoblotting, Immunoprecipitation
Area of Interest
Immunology
Clone
YN1/1.7.4
Gene ID
15894
Isotype
IgG2b, kappa
Related Products
Related Products
Scientific Resources
Product Documentation
| Document Type | Product Name | Catalog # | Lot # | Language |
|---|---|---|---|---|
|
Document Type
Product Information Sheet
|
Product Name
Anti-Mouse CD54 (ICAM-1) Antibody, Clone YN1/1.7.4
|
Catalog #
60151, 60151.1 |
Lot #
All |
Language
English |
|
Document Type
Safety Data Sheet
|
Product Name
Anti-Mouse CD54 (ICAM-1) Antibody, Clone YN1/1.7.4
|
Catalog #
60151, 60151.1 |
Lot #
All |
Language
English |
Educational Materials (2)
Brochure
Reliable Antibodies for Your Research
Wallchart
Human Immune Cytokines
Data and Publications
Data
Flow cytometry analysis of C57BL/6 mouse splenocytes labeled with Anti-Mouse CD54 (ICAM-1) Antibody, Clone YN/1.7.4, followed by a mouse anti-rat IgG2b antibody, FITC (filled histogram) or Rat IgG2b, kappa Isotype Control Antibody, Clone RTK4530 (Catalog #60077), followed by a mouse anti-rat IgG2b antibody, FITC (solid line histogram).
Quality Statement:
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
