This rabbit polyclonal antibody reacts with human villin 1, a calcium-regulated protein expressed in epithelial cells. Villin 1 is organized into six conserved domains, which make up the villin core, and a C-terminal headpiece domain, which contains an F-actin binding site. Use this polyclonal antibody in applications requiring detection of villin 1, such as western blotting (WB) assays and immunohistochemistry (IHC). It is verified for use with immunocytochemistry (ICC).

Villin 1 is an important player in the reorganization of microvillar actin filaments and is involved in actin nucleation, polymerization, and severing. It is a key component in the growth and development of intestinal epithelial cells, regulating cell morphology, growth, and apoptosis. Villin 1 has been suggested as a predictive factor in some adenocarcinomas of the endocervix, colon, and lungs. Abnormal villin expression has also been associated with biliary atresia and cholestasis.