“Neurodegenerative Diseases” Featuring Dr. Clive Svendsen
On this episode of the Stem Cell Podcast, Dr. Clive Svendsen from Cedars-Sinai talks about using stem cells to model spinal muscular atrophy and the blood-brain barrier, and his cell-gene therapy trial for ALS.
Dr. Clive Svendsen is the Executive Director of the Regenerative Medicine Institute at Cedars-Sinai. His lab uses stem cells to develop models and treatments for neurodegenerative diseases. He talks about using stem cells to model spinal muscular atrophy and the blood-brain barrier, and his cell-gene therapy trial for ALS.
Dr. Clive Svendsen is an expert in the area of neurodegeneration, and has had a productive career modeling and developing potential cell-based therapeutics for various neurodegenerative diseases. His lab also focuses on organ-on-chip strategies for modeling physiological barrier functions, and has recently even delved into space biology!
Dr. Arun Sharma, host
Find more episodes at stemcellpodcast.com or wherever you get your podcasts.
This Episode's Stem Cell Roundup:
- Embryonic Angiogenesis – Monocytes deposit migrasomes to promote angiogenesis in chick embryos.
- Stem Cell Crosstalk with the Microenvironment – Ras drives malignancy in squamous cell carcinoma through aberrant crosstalk between cancer stem cells and their microenvironment.
- The Extracellular Matrix and Naïve Pluripotency – A three-dimensional extracellular matrix-rich environment preserves long-term feeder-free naïve hiPSC self-renewal.
- Cell Senescence in Alzheimer’s Disease – Alzheimer’s disease brains have high proportions of neurons that express senescence markers.
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