Human Recombinant HBEGF

Heparin-binding EGF-like growth factor
Catalog #
78163_C
Heparin-binding EGF-like growth factor
From: 84 USD

Overview

Heparin-binding epidermal growth factor (EGF)-like growth factor (HBEGF) is a member of the EGF family (Nishi & Klagsbrun). HBEGF promotes blastocyst adhesion to the uterine wall (Iwamoto & Mekada). It also plays a role in smooth muscle cell hyperplasia and brain injury (Nishi & Klagsburn). HBEGF produced by CD4+ T cells promotes wound healing by stimulating migration and proliferation of keratinocytes, fibroblasts, and smooth muscle cells (Blotnick et al.). It binds to EGFR, ErbB4, ErbB2, and ErbB3, activating the PI3K/AKT signaling cascade (Iwamoto & Mekada). HBEGF is produced in a variety of cells, where it contributes to physiological and pathological processes. HBEGF is overexpressed in ovarian, breast, gastric, colorectal, pancreatic, and endometrial cancers, which likely contributes to pathogenesis (Miyata et al.).
Subtype
Cytokines, Growth Factors
Alternative Names
Diphtheria toxin receptor, DTR, HBEGF, Heparin binding EGF-like growth factor
Cell Type
Fibroblasts, Keratinocytes, Smooth Muscle, T Cells, CD4+
Species
Human
Area of Interest
Epithelial Cell Biology, Immunology
Molecular Weight
9.7 kDa
Purity
≥ 95%

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Human Recombinant HBEGF
Catalog #
78163
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant HBEGF
Catalog #
78163
Lot #
All
Language
English

Educational Materials (5)

Brochure
Cytokines, Chemokines and Growth Factors
Brochure
Reliable Antibodies for Your Research
Wallchart
Directed Differentiation of Pluripotent Stem Cells
Wallchart
Small Molecules, Big Impact in Cancer Research
Wallchart
Human Immune Cytokines

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

(A) The biological activity of Human Recombinant HBEGF was tested by its ability to promote the proliferation of 3T3 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 0.75 ng/mL. (B) 2 μg of Human Recombinant HBEGF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant HBEGF has a predicted molecular mass of 9.7 kDa.

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