Cerebral Organoids as 3D, Stem Cell-Derived Models of Tuberous Sclerosis Complex

In this webinar, Dr. Juergen Knoblich presents data from his preprint, "Cerebral organoid model reveals excessive proliferation of human caudal late interneuron progenitors in Tuberous Sclerosis Complex".

0:00 Studying genetic loss-of-function in animal and human models
5:18 Features of mammalian cortical development
8:59 Features of the cerebral organoid 3D culture model system
13:26 Proof-of-principle: modeling congenital microcephaly using patient-derived organoids
16:19 Modeling Tuberous Sclerosis Complex using stem cell-derived cerebral organoids
Publish Date: April 07, 2020 Views: 0