“Neuronal Diversity” Featuring Dr. Paola Arlotta
On this episode of the Stem Cell Podcast, Dr. Paola Arlotta from Harvard University talks about brain organoids as models for human development, neuropsychiatric disorders, and neurodegenerative diseases.
Dr. Paola Arlotta is the Golub Family Professor of Stem Cell and Regenerative Biology at Harvard University. She is interested in understanding the molecular laws that govern the birth, differentiation, and assembly of the human brain’s cerebral cortex. She talks about using organoids to study the genetics of autism. She also discusses single-cell sequencing of brain organoids and how to make single-cell sequencing methods and data more accessible.
Dr. Paola Arlotta is a pioneer in utilizing cerebral organoids to model neurodevelopmental disorders. We discuss what it takes to make the best models for studying human disease, as well as model environments (such as the Boston area) for taking basic science discoveries into the clinic.
Dr. Arun Sharma, host
Find more episodes at stemcellpodcast.com or wherever you get your podcasts.
This Episode's Stem Cell Roundup:
- Reactivating Neurons After Paralysis – Scientists identified a population of excitatory interneurons that are essential for the recovery of walking with epidural electrical stimulation following spinal cord injury.
- Lamin A/C, Chromatin Organization, and Cardiomyopathy – Researchers uncovered divergent functions of lamin A/C in naïve pluripotent stem cells and cardiomyocytes.
- HSC Colonization of the Bone Marrow – Scientists identified ligand-receptor pairs likely to be involved in fetal HSC migration and maintenance.
- Rhinoceros Organoids – Researchers generated iPSCs from a Sumatran rhino, characterized them comprehensively, and differentiated them into cerebral organoids.
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