“Autoimmune Disease” Featuring Dr. Jennifer Gommerman
On this episode of the Immunology Podcast, Dr. Jennifer Gommerman talks about the role of gut-derived plasma cells in multiple sclerosis, and how salivary immunoglobulin A can protect against breakthrough COVID-19 infections.
Dr. Jennifer Gommerman is a Professor of Immunology at the University of Toronto. Her team has uncovered a novel gut-brain axis that regulates neuroinflammation and is examining the role of B lymphocytes in multiple sclerosis (MS) patients and in animal models of MS. More recently, she has been studying the antibody response to SARS-CoV-2 in saliva samples from patients with COVID-19. She talks about the role of gut-derived plasma cells in multiple sclerosis, and how salivary immunoglobulin A can protect against breakthrough COVID-19 infections.
Dr. Gommerman refreshes on the importance of non-IgG-mediated B cell responses, and, in particular, the unsung immunoglobulin hero, IgA!
Dr. Jason Goldsmith, host
Find more episodes at immunologypodcast.com or wherever you get your podcasts.
This Episode's Immunology Roundup:
- Neutralizing Antibody Responses to Omicron – SARS-CoV-2-specific immunity wanes over time after two mRNA vaccine doses.
- Determining T Cell Fate – Researchers identified T cell antigen receptor sequence features that promote regulatory T cell fate.
- Fungi in the Gut – Mucosa-associated fungi protect mice against intestinal injury and infection via interleukin-22-dependent mechanisms.
- T Cells in Glioblastomas – T cell dysfunction in the glioblastoma microenvironment is mediated by myeloid cells releasing interleukin-10.
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