HIV reverse transcriptase inhibitor
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Stavudine has been used for:
· Induces mitochondrial reactive oxygen species (ROS) and enhances mitochondrial oxidative stress in human hepatoma cells (Velsor et al.).
· Reported to induce cellular senescence in human fibroblasts. Fibroblasts treated with stavudine exhibited mitochondrial dysfunction, slowed division rates, and increased ROS levels in early culture passages. In later passages, fibroblasts became senescent on the basis of p16 and p21 protein expression and senescence-associated-beta-galactosidase activity (Caron et al.).
· Reduces NLRP3 inflammasome-associated inflammation and stimulates Aβ autophagy by THP-1-derived macrophages in an in vitro model of Alzheimer's disease (La Rosa et al.).
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Resources and Publications
Educational Materials (5)
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PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.