AK-7
Selective sirtuin 2 inhibitor
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Overview
AK-7 has been used for:
DISEASE MODELING
· Protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity and α‐Synuclein (aSyn) toxicity in Parkinson’s disease mouse models (Chen et al.).
· Promotes neuronal survival in Huntington’s disease mouse models (Chopra et al.).
· Improves the outcome of brain ischemia in mice by reportedly enhancing P38 activation levels in vitro and in vivo, significantly decreasing infarction volume, as well as promoting the recovery of neurological function in mice evaluated in behavior tests (Wu et al.).
· Decreases cochlear cell apoptosis and attenuates noise-induced hearing loss, as well as reduces oxidative nuclear DNA damage and apoptosis in mouse cochlea following noise exposure. AK-7 has also been shown to reduce apoptosis of mouse inner ear HEI-OC1 cells exposed to oxidative stress in vitro (Liu et al.).
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Resources and Publications
Educational Materials (5)
Quality Statement:
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.