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Regulate cancer cell apoptosis with ABT-263, a chemotherapeutic agent and an inhibitor of B cell lymphoma 2 (Bcl-2), B cell lymphoma-extra large (Bcl-xL), and Bcl-2-like protein 2 (Bcl-W) (Ki = < 1 nM, < 0.5, and < 1 nM, respectively). Bcl-2 and Bcl-xL are anti-apoptotic proteins that regulate cell death by interacting with pro-apoptotic proteins, like Bcl-2-like protein 11 (BIM), to induce or inhibit apoptosis (Tse et al.). ABT-263 displaces Bcl-xL from binding to BIM, allowing cells to undergo apoptosis (Lagares et al.).
ABT-263 has been used for:
IMMUNOLOGY
· Reduces expression of mitochondrial antiviral signaling protein (MAVS) in macrophages (Kim et al.).
· Induces apoptosis in influenza A virus-infected cells by activating the caspase 9-mediated mitochondrial apoptosis pathway (Kakkola et al.).
CANCER RESEARCH
· Inhibits tumor growth in small cell lung cancer xenograft models (Aguilar et al.).
· Acts as a selective senolytic in vitro by inducing apoptosis in senescent tumor cells after induction into senescence by chemotherapy or radiation (Saleh et al.).
· Promotes apoptosis in senescent murine Lewis lung carcinoma (LLC) cells (Saleh et al.).
· Induces G1/G0-phase arrest, apoptosis, and autophagy in human esophageal cancer cells (EC109, HKESC-2, and CaES-17) in vitro (Lin et al.).
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
