Human Peripheral Blood Plasma, Frozen

Primary human plasma, frozen
From: 93 USD

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Primary human plasma, frozen
From: 93 USD

Overview

Primary human plasma has been isolated from peripheral blood (PB) using centrifugation. PB was collected using one of the following anticoagulants: acid-citrate-dextrose (ACD), acid-citrate-dextrose solution A (ACDA), citrate-phosphate-dextrose (CPD), citrate-phosphate-double-dextrose (CP2D), or citrate-phosphate-dextrose-adenine (CPDA).

Plasma was obtained using Institutional Review Board (IRB)-approved consent forms and protocols.

Certain products are only available in select territories. Please contact your local Sales representative or Product & Scientific Support at techsupport@stemcell.com for further information.
Subtype:
Frozen
Cell Type:
Plasma Cells
Species:
Human
Cell and Tissue Source:
Peripheral Blood
Donor Status:
Normal

Scientific Resources

Product Documentation

Document Type
Product Name
Catalog #
Lot #
Language
70039, 70039.1, 70039.2, 70039.3, 70039.4, 70039.5, 70039.6
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Educational Materials

(2)

Data and Publications

Publications

(1)
Cell 2018 JAN

Intrinsic Immunity Shapes Viral Resistance of Stem Cells.

Wu X et al.

Abstract

Stem cells are highly resistant to viral infection compared to their differentiated progeny; however, the mechanism is mysterious. Here, we analyzed gene expression in mammalian stem cells and cells at various stages of differentiation. We find that, conserved across species, stem cells express a subset of genes previously classified as interferon (IFN) stimulated genes (ISGs) but that expression is intrinsic, as stem cells are refractory to interferon. This intrinsic ISG expression varies in a cell-type-specific manner, and many ISGs decrease upon differentiation, at which time cells become IFN responsive, allowing induction of a broad spectrum of ISGs by IFN signaling. Importantly, we show that intrinsically expressed ISGs protect stem cells against viral infection. We demonstrate the in vivo importance of intrinsic ISG expression for protecting stem cells and their differentiation potential during viral infection. These findings have intriguing implications for understanding stem cell biology and the evolution of pathogen resistance.
STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.