Human Recombinant Serpin A12

Serpin A12, His tag

Human Recombinant Serpin A12

Serpin A12, His tag

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Serpin A12, His tag
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Overview

Commonly known as vaspin, Serpin A12 is an adipokine that is thought to perform insulin-sensitizing functions, such as the regulation of kallikrein 7 (KLK7), an insulin-inhibiting protease (Heiker et al.). The Serpin A12 glycoprotein belongs to the serine protease inhibitor family (serpin), and is mainly associated with obesity, insulin resistance, and glucose metabolism, but may also protect against high fat-induced bone loss (Wang et al.). Serpins share a highly conserved core structure with multiple α-helices, β-strands, and a reactive site loop (RCL) to interact with the target protease (Huntington). It is expressed predominantly in visceral adipose tissue and at significantly higher amounts in obese individuals (Kurowska et al.). This protein contains a His-residue tag at the carboxyl end of the polypeptide chain. For consistency and reproducibility across your applications, Serpin A12 from STEMCELL comes lyophilized with ≥ 94% purity, and is verified by LAL analysis to ensure endotoxin levels are ≤ 1.0 EU/μg protein.
Subtype
Cytokines
Alternative Names
OL-64, Vaspin
Species
Human
Area of Interest
Metabolism
Purity
≥ 94%

Data Figures

Human Recombinant Serpin A12 was resolved with SDS-PAGE under reducing (+) conditions and visualized by Coomassie Blue staining. Human Recombinant Serpin A12 has a predicted molecular mass of 46.5 kDa and an apparent molecular mass of 50 - 55 kDa due to glycosylation.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
100-1326
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
100-1326
Lot #
All
Language
English