Human Recombinant Apolipoprotein H

Apolipoprotein H, His tag

Human Recombinant Apolipoprotein H

Apolipoprotein H, His tag

From: 614 USD
Catalog #
100-1332_C
Apolipoprotein H, His tag
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Overview

Apolipoprotein H (apo H) has been shown to promote the coagulation of blood platelets by inhibiting thrombomodulin complex and inactivating protein C (Keeling et al.), but can also act as an anticoagulant by binding thrombin and inhibiting its procoagulant effects (Pozzi et al.). Belonging to the lipid-binding apolipoprotein family, within the lipocalin superfamily, apo H is a protein constituent of plasma, with a high affinity for negatively charged phospholipids. The structure of apo H reveals four N-terminal complement control protein (CCP) modules, also known as “sushi” domains, and a distinct fifth C-terminal domain with four antiparallel beta sheets, two alpha-helices, and an extended loop (Schwarzenbacher et al.). Apo H is the main antigen implicated in antiphospholipid syndrome (APS), an autoimmune condition involving pregnancy complications and vascular thrombosis (Brusch). Studies have also reported that Apo H is involved in the progression of atherosclerosis (Harats and George). This protein contains a His-residue tag at the carboxyl end of the polypeptide chain. For consistency and reproducibility across your applications, apolipoprotein H from STEMCELL comes lyophilized with ≥ 93% purity, and is verified by LAL analysis to ensure endotoxin levels are ≤ 1.0 EU/μg protein.
Subtype
Cytokines
Alternative Names
B2G1, β2GP1, β2GPI, BG
Species
Human
Area of Interest
Metabolism
Purity
≥ 93%

Data Figures

Human Recombinant Apolipoprotein H was resolved with SDS-PAGE under reducing (+) conditions and visualized by Coomassie Blue staining. Human Recombinant Apolipoprotein H has a predicted molecular mass of 37.7 kDa and an apparent molecular mass of 53 kDa due to glycosylation.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
100-1332
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
100-1332
Lot #
All
Language
English