Human Recombinant 15-PGDH

15-Hydroxyprostaglandin dehydrogenase, His tag

Human Recombinant 15-PGDH

15-Hydroxyprostaglandin dehydrogenase, His tag

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15-Hydroxyprostaglandin dehydrogenase, His tag
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Overview

Modulate prostaglandin metabolism with 15-hydroxyprostaglandin dehydrogenase (15-PGDH). 15-PGDH catalyzes the reversible oxidation of the 15-hydroxyl group in prostaglandins, resulting in inactivated metabolites (Ensor and Tai), it can act on a variety of prostaglandins as substrates in a NAD+ dependent manner (Cho et al.). As prostaglandins can have a range of effects on cellular processes, 15-PGDH is of considerable importance in drug development. In vitro and in vivo studies suggest 15-PGDH has tumor suppressive activity and is downregulated in certain cancers (Na et al.).15-PGDH belongs to the short-chain dehydrogenases/reductases (SDR) family; its primary structure indicates 20% homology with other SDRs, with some conserved amino acid residues (Krook et al.). This protein contains a His-residue tag at the carboxyl end of the polypeptide chain. For consistency and reproducibility across your applications, apo M from STEMCELL comes lyophilized with ≥ 89% purity.
Subtype
Cytokines
Alternative Names
PGDH, PGDH1, PHOAR1, SDR36C1
Species
Human
Area of Interest
Metabolism
Purity
≥ 89%

Data Figures

Human Recombinant 15-PGDH was resolved with SDS-PAGE under reducing (+) conditions and visualized by Coomassie Blue staining. Human Recombinant 15-PGDH has a predicted molecular mass of 29.7 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
100-1329
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
100-1329
Lot #
All
Language
English