FK-866

Nicotinamide phosphoribosyltransferase inhibitor

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Nicotinamide phosphoribosyltransferase inhibitor
From: 119 USD

Overview

FK-866 is a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme that regulates NAD+ biosynthesis from the natural precursor nicotinamide (Cameron et al.; Hasmann & Schemainda). In hepatocarcinoma cells, FK-866 activates AMP-activated protein kinase (AMPK) and downregulates mammalian target of rapamycin (mTOR) signaling (Schuster et al.).

METABOLISM
· FK-866 can be used to deplete NAD+, a central metabolism cofactor (Cameron et al.; Hasmann & Schemainda; Jadeja et al.).

CANCER RESEARCH
· Depletes NAD+ and induces delayed cell death by apoptosis in HepG2 human liver carcinoma cells (IC₅₀ = ~1 nM; Hasmann & Schemainda).
· Triggers dose-dependent cytotoxicity in multiple myeloma cells (Cea et al.).
· Induces autophagic death in neuroblastoma SH-SY5Y cells (IC₅₀ = 0.93 nM; Billington et al.).

Alternative Names:
K 22.175
CAS Number:
658084-64-1
Chemical Formula:
C₂₄H₂₉NO
Molecular Weight:
391.5 g/mol
Purity:
≥ 98%
Pathway:
mTOR
Target:
AMPK

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PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.