BMN 673

Poly ADP ribose polymerase (PARP) inhibitor

BMN 673

Poly ADP ribose polymerase (PARP) inhibitor

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Poly ADP ribose polymerase (PARP) inhibitor
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Overview

Inhibit poly ADP ribose polymerase (PARP) with BMN 673 (PARP1 IC50 = 0.57 nM; Shen et al.). BMN 673 binds to PARP in cancer cells with BRCA1, BRCA2, or PTEN mutations and prevents PARP-mediated repair of single-strand DNA breaks, leading to DNA damage (Shen et al.).

BMN 673 has been used for:

CANCER RESEARCH
· Traps PARP1 at the DNA damage site and induces cytotoxic effects in breast cancer cells (Sethy & Kundu).
· Increases the number of CD8+ T cells and NK cells, as well as production of IFN-γ and TNF-α, to inhibit growth of BRCA1-deficient murine epithelial ovarian cancer cell line BR5FVB1-Akt (Huang et al.).
· Inhibits BRCA2-associated pancreatic ductal adenocarcinoma (PDAC) growth in a PDAC murine xenograft model (Andrei et al.).
Cell Type
Cancer Cells and Cell Lines
Area of Interest
Cancer
CAS Number
1207456-01-6
Chemical Formula
C₁₉H₁₄F₂N₆O
Molecular Weight
380.4 g/mol
Purity
≥ 98%

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Product Name
BMN 673
Catalog #
100-1129
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
BMN 673
Catalog #
100-1129
Lot #
All
Language
English

Resources and Publications