ABT-888 (Dihydrochloride)

PARP1 and PARP2 inhibitor

ABT-888 (Dihydrochloride)

PARP1 and PARP2 inhibitor

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PARP1 and PARP2 inhibitor
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Overview

Inhibit cancer cell growth by inhibiting poly ADP ribose polymerase (PARP) with ABT-888 (Dihydrochloride). With a high affinity for both PARP1 and PARP2 (IC50 = 5.2 and 2.9 nM), ABT-888 is inactive against sirtuin 2 (Donawho et al.). ABT-888 inhibits PARPs and prevents them from repairing DNA breaks during DNA replication, which leads to DNA damage and apoptosis (Javle & Curtin).

ABT-888 has been used for:

CANCER RESEARCH
· Inhibits the growth of Capan1 cells with BRCA 2 mutations (Cincinelli et al.).
· Inhibits colony growth of PC-3 tumors, though no effect in DU-145 tumors has been found (Barreto-Andrade et al.).
Cell Type
Cancer Cells and Cell Lines
Area of Interest
Cancer
CAS Number
912445-05-7
Chemical Formula
C13H16N4O • 2HCl
Molecular Weight
317.2 g/mol
Purity
≥ 98%

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
100-1170
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
100-1170
Lot #
All
Language
English

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