· Increases the efficiency of reprogramming mouse and human fibroblasts to induced pluripotent stem (iPS) cells (Esteban et al.) partly through JHDM1 histone demethylase activity (Wang et al.).
· Prevents aberrant DNA methylation of the Dlk1-Dio3 locus during reprogramming of mouse somatic cells to iPS cells (Stadtfeld et al.).
MAINTENANCE AND SELF-RENEWAL
· Supports proliferation of mesenchymal stem cells (Choi et al.).
· Promotes differentiation of osteoblasts from human and mouse mesenchymal cells (Pittenger et al.; Tropel et al.).
· Promotes differentiation of osteoblasts from mouse embryonic stem (ES) cells (zur Nieden et al.).
· Enhances differentiation of cardiomyocytes from mouse ES cells (Takahashi et al.).
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