Human Peripheral Blood Plasma, Frozen
Primary human plasma, frozen
Overview
Primary human plasma has been isolated from peripheral blood (PB) using centrifugation. PB was collected using one of the following anticoagulants: acid-citrate-dextrose (ACD), acid-citrate-dextrose solution A (ACDA), citrate-phosphate-dextrose (CPD), citrate-phosphate-double-dextrose (CP2D), or citrate-phosphate-dextrose-adenine (CPDA).
Plasma was obtained using Institutional Review Board (IRB)-approved consent forms and protocols.
Certain products are only available in select territories. Please contact your local Sales representative or Product & Scientific Support at techsupport@stemcell.com for further information.
Plasma was obtained using Institutional Review Board (IRB)-approved consent forms and protocols.
Certain products are only available in select territories. Please contact your local Sales representative or Product & Scientific Support at techsupport@stemcell.com for further information.
Subtype
Frozen
Species
Human
Cell and Tissue Source
Plasma, Peripheral Blood
Donor Status
Normal
Related Products
Related Products
Scientific Resources
Product Documentation
| Document Type | Product Name | Catalog # | Lot # | Language |
|---|---|---|---|---|
|
Document Type
Product Information Sheet
|
Product Name
Human Peripheral Blood Plasma, Frozen
|
Catalog #
70039, 70039.1, 70039.2, 70039.3, 70039.4, 70039.5, 70039.6 |
Lot #
All |
Language
English |
Educational Materials (2)
Brochure
Tools For Your Immunology Research
Brochure
Human Primary Cells
Data and Publications
Publications (1)
Cell 2018 JAN
Intrinsic Immunity Shapes Viral Resistance of Stem Cells.
Abstract
Abstract
Stem cells are highly resistant to viral infection compared to their differentiated progeny; however, the mechanism is mysterious. Here, we analyzed gene expression in mammalian stem cells and cells at various stages of differentiation. We find that, conserved across species, stem cells express a subset of genes previously classified as interferon (IFN) stimulated genes (ISGs) but that expression is intrinsic, as stem cells are refractory to interferon. This intrinsic ISG expression varies in a cell-type-specific manner, and many ISGs decrease upon differentiation, at which time cells become IFN responsive, allowing induction of a broad spectrum of ISGs by IFN signaling. Importantly, we show that intrinsically expressed ISGs protect stem cells against viral infection. We demonstrate the in vivo importance of intrinsic ISG expression for protecting stem cells and their differentiation potential during viral infection. These findings have intriguing implications for understanding stem cell biology and the evolution of pathogen resistance.
Quality Statement:
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