Human Peripheral Blood Plasma, Frozen

Primary human plasma, frozen

Human Peripheral Blood Plasma, Frozen

Primary human plasma, frozen

From: 124 USD
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Primary human plasma, frozen
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Overview

Primary human plasma has been isolated from peripheral blood (PB) using centrifugation. PB was collected using one of the following anticoagulants: acid-citrate-dextrose (ACD), acid-citrate-dextrose solution A (ACDA), citrate-phosphate-dextrose (CPD), citrate-phosphate-double-dextrose (CP2D), or citrate-phosphate-dextrose-adenine (CPDA).

Plasma was obtained using Institutional Review Board (IRB)-approved consent forms and protocols.

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Subtype
Frozen
Species
Human
Cell and Tissue Source
Peripheral Blood, Plasma

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
70039.1, 70039, 70039.6, 70039.2, 70039.3, 70039.4, 70039.5
Lot #
All
Language
English

Resources and Publications

Educational Materials (2)

Publications (1)

Intrinsic Immunity Shapes Viral Resistance of Stem Cells. Wu X et al. Cell 2018 JAN

Abstract

Stem cells are highly resistant to viral infection compared to their differentiated progeny; however, the mechanism is mysterious. Here, we analyzed gene expression in mammalian stem cells and cells at various stages of differentiation. We find that, conserved across species, stem cells express a subset of genes previously classified as interferon (IFN) stimulated genes (ISGs) but that expression is intrinsic, as stem cells are refractory to interferon. This intrinsic ISG expression varies in a cell-type-specific manner, and many ISGs decrease upon differentiation, at which time cells become IFN responsive, allowing induction of a broad spectrum of ISGs by IFN signaling. Importantly, we show that intrinsically expressed ISGs protect stem cells against viral infection. We demonstrate the in vivo importance of intrinsic ISG expression for protecting stem cells and their differentiation potential during viral infection. These findings have intriguing implications for understanding stem cell biology and the evolution of pathogen resistance.