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Y-27632

RHO/ROCK Pathway Inhibitor; Inhibits ROCK

  • Chemical structure of Y-27632 (Dihydrochloride)
  • Vial label for Y-27632 (Dihydrochloride), 1 mg
  • Vial label for Y-27632 (Dihydrochloride), 5 mg
  • Vial label for Y-27632 (Dihydrochloride), 10 mg
  • Vial label for Y-27632 (Dihydrochloride), 50 mg
Chemical structure of Y-27632 (Dihydrochloride)
Product Catalog # Size Price
Y-27632 (Dihydrochloride)
RHO/ROCK pathway inhibitor Inhibits ROCK
72302 1 mg 119.00 USD
Y-27632 (Dihydrochloride)
RHO/ROCK pathway inhibitor Inhibits ROCK
72304 5 mg 199.00 USD
Y-27632 (Dihydrochloride)
RHO/ROCK pathway inhibitor Inhibits ROCK
72307 5 x 10 mg 1116.00 USD
Y-27632 (Dihydrochloride)
RHO/ROCK pathway inhibitor Inhibits ROCK
72308 50 mg 849.00 USD
 

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Quick Order

  • Y-27632 (Dihydrochloride) (72302)
    1 mg
    119.00 USD

  • Y-27632 (Dihydrochloride) (72304)
    5 mg
    199.00 USD

  • Y-27632 (Dihydrochloride) (72307)
    5 x 10 mg
    1116.00 USD

  • Y-27632 (Dihydrochloride) (72308)
    50 mg
    849.00 USD

Description


Y-27632 is a cell-permeable, highly potent and selective inhibitor of Rho-associated, coiled-coil containing protein kinase (ROCK). Y-27632 inhibits both ROCKI (Ki = 220 nM) and ROCKII (Ki = 300 nM) by competing with ATP for binding to the catalytic site. (Davies et al., Ishizaki et al.)
 
Published Applications
MAINTENANCE:
  • Enhances survival of human embryonic stem (ES) cells when they are dissociated to single cells by preventing dissociation-induced apoptosis (anoikis), thus increasing their cloning efficiency. (Watanabe et al.)
  • Improves embryoid body formation using forced-aggregation protocols. (Ungrin et al.)
  • Increases the survival of cryopreserved single human ES cells after thawing. (Li et al.)
  • Target: ROCK Inhibitor
    Pathway: RHO/ROCK
    Application: Maintenance
    CAS Number: 129830-38-2
    Chemical Formula:
    C₁₄H₂₁N₃O · 2HCl
    Molecular Weight: 320.3 g/mol
    Alternate Names: Not applicable
    Product Type: Small Molecules
    Purity: ≥ 98%
    Area of Interest: Embryonic stem cell & iPS cell research
    Cell Type: Embryonic stem cells & iPS cells
    Species: Human
    Intended Use Statement: FOR RESEARCH USE ONLY. NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES.

    Technical Resources


    Protocols and Manuals

    Current documents
    Product NameLot # ?Document TypeDownload
    Y-27632 (Dihydrochloride) All Product Information Sheet

    MSDS

    Educational Resources

    Brochures

  • Small Molecules for Stem Cell Research
  • Small Molecules For Cancer Research
  • Wallcharts

  • Small Molecules, Big Impact in Pluripotent Stem Cell Research Wallchart

     

    Data


    Related Products


    Other Reagents and Materials


    Product Name

    Description

    Catalog #

    mTeSR™1 Defined, Feeder-Free Maintenance Medium for Human ES and iPS Cells 05850
    TeSR™-E7™ Feeder-Free, Xeno-Free Reprogramming Medium for Human iPS Cell Induction 05910

    Small Molecules


    Product Name

    Description

    Catalog #

    Thiazovivin RHO/ROCK Pathway Inhibitor; Inhibits ROCK 72252

    Publications


    Background References:


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