Y-27632

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RHO/ROCK Pathway Inhibitor; Inhibits ROCK

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  • Chemical structure of Y-27632 (Dihydrochloride)
  • Vial label for Y-27632 (Dihydrochloride), 1 mg
  • Vial label for Y-27632 (Dihydrochloride), 5 mg
  • Vial label for Y-27632 (Dihydrochloride), 10 mg
Chemical structure of Y-27632 (Dihydrochloride)
Y-27632 is a cell-permeable, highly potent and selective inhibitor of Rho-associated, coiled-coil containing protein kinase (ROCK). Y-27632 inhibits both ROCKI (Ki = 220 nM) and ROCKII (Ki = 300 nM) by competing with ATP for binding to the catalytic site. (Davies et al., Ishizaki et al.)
 
Published Applications
MAINTENANCE:
  • Enhances survival of human embryonic stem (ES) cells when they are dissociated to single cells by preventing dissociation-induced apoptosis (anoikis), thus increasing their cloning efficiency. (Watanabe et al.)
  • Improves embryoid body formation using forced-aggregation protocols. (Ungrin et al.)
  • Increases the survival of cryopreserved single human ES cells after thawing. (Li et al.)
  • Product Name Description Catalog # Size Price Quantity
    Y-27632 (Dihydrochloride) RHO/ROCK pathway inhibitor Inhibits ROCK 72302 1 mg 119.00 USD      
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    Y-27632 (Dihydrochloride) RHO/ROCK pathway inhibitor Inhibits ROCK 72304 5 mg 499.00 USD      
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    Y-27632 (Dihydrochloride) RHO/ROCK pathway inhibitor Inhibits ROCK 72307 5 x 10 mg 1116.00 USD      
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    Target: ROCK Inhibitor
    Pathway: RHO/ROCK
    Application: Maintenance
    CAS Number: 129830-38-2
    Chemical Formula:
    C₁₄H₂₁N₃O · 2HCl
    Molecular Weight: 320.3 g/mol
    Alternate Names: 4-​[(1R)-​1-​aminoethyl]-​N-​4-​pyridinyl-​trans-​cyclohexanecarboxamide,​ dihydrochloride
    Product Type: Small Molecules
    Purity: ≥ 98%
    Area of Interest: Embryonic stem cell & iPS cell research
    Cell Type: Embryonic stem cells & iPS cells
    Species: Human
    Intended Use Statement: FOR RESEARCH USE ONLY. NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES.

    Protocols and Manuals

    Current documents
    Product NameLot# ?Document TypeDownload
    Y-27632 (Dihydrochloride) All Product Information Sheet
     

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    MSDS:

     

    Product Name

    Description

    Catalog #

    Thiazovivin RHO/ROCK Pathway Inhibitor; Inhibits ROCK 72252
    mTeSR™1 Defined, Feeder-Free Maintenance Medium for Human ES and iPS Cells 05850
    TeSR™-E7™ Feeder-Free, Xeno-Free Reprogramming Medium for Human iPS Cell Induction 05910

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