Valproic Acid (Sodium Salt)

Epigenetic modifier; Inhibits histone deacetylase (HDAC)1

Valproic Acid (Sodium Salt)

Epigenetic modifier; Inhibits histone deacetylase (HDAC)1

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Epigenetic modifier; Inhibits histone deacetylase (HDAC)1
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Overview

Valproic Acid (VPA) is a short-chain fatty acid that acts as an epigenetic modifier by inhibiting Histone Deacetylases (HDACs) with IC₅₀ values ranging from 0.4 - 3 mM. VPA can also increase γ­aminobutyric acid (GABA) levels via inhibition of enzymes involved in GABA metabolism. Other effects include depletion of cellular inositol by inhibiting myo-inositol-1-phosphate synthase. (Gottlicher et al., Khan et al., Phiel et al., Rosenberg)

REPROGRAMMING
· Enables chemical reprogramming (without genetic factors) of mouse embryonic fibroblasts to induced pluripotent stem (iPS) cells, in combination with CHIR99021, Forskolin, Tranylcypromine, 3-Deazaneplanocin A, and E-616452 (Hou et al.).
· Increases the reprogramming efficiency of mouse embryonic fibroblasts to iPS cells (Huangfu et al. 2008a).
· Promotes reprogramming of human fibroblasts to iPS cells using only 2 factors, OCT4 and SOX2 (Huangfu et al. 2008b).
· Direct lineage reprogramming of fibroblasts to mature neurons, in combination with CHIR99021, RepSox, Forskolin, SP600125, Gö6983 and Y-27632 (Hu et al.).

MAINTENANCE AND SELF-RENEWAL
· Mediates ex vivo expansion of cord blood CD34+ hematopoietic stem and progenitor cells (Chaurasia et al.).
· Promotes the proliferation and self-renewal of human and mouse hematopoietic progenitor cells (Bug et al., De Felice et al.).

DIFFERENTIATION
· Promotes differentiation of neurons and suppresses differentiation of astrocytes and oligodendrocytes from rat neural progenitor cells (Hsieh et al., Jung et al.).
· Promotes osteogenic differentiation of human mesenchymal stem cells (Cho et al.).
Alternative Names
2-Propylvaleric acid;Sodium valproate;VPA
Cell Type
Hematopoietic Stem and Progenitor Cells, Mesenchymal Stem and Progenitor Cells, Neurons, Osteoblasts, Pluripotent Stem Cells
Species
Human, Mouse, Non-Human Primate, Other, Rat
Application
Differentiation, Expansion, Maintenance, Reprogramming
Area of Interest
Neuroscience
CAS Number
1069-66-5
Chemical Formula
C₈H₁₅O₂ · Na
Molecular Weight
166.2 g/mol
Purity
≥ 95%
Pathway
Epigenetic
Target
HDAC

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
100-1053, 72292
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
100-1053
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
72292
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.