Elevate Your Research

ISSCR 2022: Virtual Conference Exhibition

Immerse yourself in the latest research alongside world-leading scientists in stem cell science and regenerative medicine. Whether you’re joining us in person in San Francisco or logging on virtually, be sure to connect with us from June 15 - 18 to learn how we can work with you to elevate your research and celebrate 20 years of scientific excellence at ISSCR!

Browse through sessions, resources, and upcoming products below for your stem cell research. Scientific talks and posters presented at ISSCR will be available here following the conference; don’t forget to bookmark this page and follow @STEMCELLTech on Twitter to keep up to date with the latest updates.

Join Us at ISSCR 2022

Wednesday June 15

8:30 a.m. - 11:30 a.m.

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COREdinates Focus Session: Consistent, Reproducible Differentiation of High-Quality hPSCs Using STEMdiff™ and TeSR™-AOF

Speaker: Kim Snyder, MSc | Senior Scientist

Location: Room 2004
6:30 p.m. - 7:30 p.m.

Poster: Robust Workflows for the Expansion and Differentiation of Human Pluripotent Stem Cells as Aggregates in Suspension Culture

Speaker: Eric Jervis, PhD | Senior Principal Scientist

Details: Poster #521 | Poster Session 1
6:30 p.m. - 7:30 p.m.

Poster: Efficient Differentiation of Human Pluripotent Stem Cells to Sensory Neurons

Speaker: Alym Moosa, MSc | Scientist

Details: Poster #381 | Poster Session 1
7:30 p.m. - 8:30 p.m.

Poster: Expansion and Downstream Differentiation Potential of Human Pluripotent Stem Cells (hPSCS) Maintained in GMP Animal Origin-Free Media

Speaker: Kim Snyder, MSc | Senior Scientist

Details: Poster #220 | Poster Session 1

Thursday June 16

8:00 a.m. - 8:30 a.m.

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Innovation Showcase: How to Choose the Right Neural Cell Culture Model for Your Research Question

Speaker: Erin Knock, PhD | Associate Director, Neural Biology

Location: Room 2001
Speaker Bio: Erin Knock, PhD, is the Associate Director of Neural Biology in the R&D Department at STEMCELL Technologies and an Adjunct Professor of Biology at Simon Fraser University. She obtained her PhD in Human Genetics from McGill University in 2009, followed by post-doctoral fellowships at the University of Cambridge (2009-2012) and the University of Toronto (2012-2016). In 2016, Erin was recruited to STEMCELL Technologies where she oversees the development of products for primary and stem cell-derived neural cell culture.
Abstract: Examining the nervous system at a cellular and molecular level is foundational to interpreting anatomical and psychological studies from live subjects, and choosing the optimal model for your question is key to obtaining relevant results. This Innovation Showcase will review the use of in vitro model systems and offer specific examples of the types of questions that can be answered with each model. Cultured rodent primary neurons provide mature cell types for neurotoxicity studies; we will present an example using BrainPhys™ medium to support and characterize neuron activity. For human context in flexible workflows, we will provide examples using STEMCELL’s STEMdiff™ product line to generate human pluripotent stem cell-derived cell types, such as pure sensory neuron cultures for pain modeling. Applications of culture systems with increasing complexity, such as neuron-astrocyte-microglia co-cultures for injury modeling and gene-edited organoid cultures for developmental modeling, will also be discussed. Throughout this session, we will demonstrate how STEMCELL’s tools can help overcome technical barriers to human stem cell culture and differentiation and enable the culture of complex, multi-cellular constructs when they are relevant.
11:30 a.m. - 12:15 p.m.

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Meet Up: Careers in Biotech

Speaker: Tim Le Fevre, BSc | Senior Scientist
Description: Have you ever wondered what it would be like to work in biotech? Join us to learn about the many career opportunities at STEMCELL, ask any questions you might have, and network with STEMCELL employees & other like-minded scientists. You can also visit jobs.stemcell.com for a full list of current postings.
11:30 a.m. - 12:30 p.m.

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Innovation Showcase: Robust Workflows for the Expansion of Pluripotent Stem Cells in 3D Suspension Culture

Speaker: Eric Jervis, PhD | Senior Principal Scientist

Location: Room 2007
Speaker Bio: Dr. Eric Jervis completed his PhD in Chemical Engineering at the University of British Columbia in 1998. Upon his graduation, he held a faculty position at the University of Waterloo in Chemical Engineering and left in 2011 to head the new BioEngineering Program in R&D at STEMCELL Technologies. Dr. Jervis was a founding member of the Canadian Stem Cell Network NCE, and has 51 publications in refereed journals, 2 published book chapters, more than 100 abstracts, and is co-inventor of 8 US patents.
Abstract: A challenge for scalable culture of human pluripotent stem cells (hPSC) is the lack of reproducible methods to do so without prior adaptation of cells to the higher shear levels imposed in stirred suspension. A critical balance exists between the agitation rate required to maintain aggregates in suspension and agitation-generated shear. We tested various agitation methods for their ability to maintain aggregate suspensions and cell growth rates. Experiments in which cells were serially expanded in suspension cultures up to 500 mL were conducted with 6 different cell lines (3 ESC and 3 iPSC) cultured in STEMCELL’s portfolio of TeSR™ 3D-based media products, developed specifically for robust and scalable suspension culture of hPSCs in aggregates. Aggregates were non-enzymatically passaged using Gentle Cell Dissociation Reagent and filter-based trituration. We found that the PBS-MINI MagDrive Bioreactor with a low-shear Vertical-Wheel® impeller design provided the most reproducible growth across cell lines. With this workflow, hPSCs underwent greater than 1.5- to 1.9-fold expansion per day while maintaining the hallmarks of hPSC quality. Our work demonstrates that the combination of TeSR™ 3D workflows and low-shear bioreactors provides a robust, scalable system suitable for the expansion of a wide range of hPSC lines.
3:00 p.m. - 4:00 p.m.

Poster: Robust Establishment and Expansion of Human Pancreatic Duct Organoids in Pancreacult™ Organoid Medium Kits

Speaker: Nina Quiskamp, PhD | Senior Scientist

Details: Poster #631 | Poster Session 2
3:00 p.m. - 4:00 p.m.

Poster: In Vitro Modeling of Human Vasculature Using Blood Vessel Organoids Provides a Robust Platform for Studying Blood Vessels in Normal and Pathological Conditions

Speaker: Valentina Marchetti, PhD | Senior Scientist

Details: Poster #829 | Poster Session 2
3:00 p.m. - 4:00 p.m.

Poster: Generation of a Glia-Midbrain Neuron Co-Culture System Derived From Human Pluripotent Stem Cells

Speaker: Noëmie LeBlanc, MSc | Senior Research Associate

Details: Poster #379 | Poster Session 2
3:00 p.m. - 5:00 p.m.

Drop-In: Stem Cell Podcast Recording

Description: Interested in being featured on an episode of the Stem Cell Podcast? Stop by our on-site studio to share your thoughts on the meeting and the future of stem cell research.

Location: Room 2204
4:00 p.m. - 5 :00 p.m.

Poster: Robust and Efficient Generation of Functional Human Pluripotent Stem Cell-Derived Atrial Cardiomyocytes

Speaker: Jessica Legree, B.Sc | Technical Scientist

Details: Poster #304 | Poster Session 2

Friday June 17

8:00 a.m. - 8:30 a.m.

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Innovation Showcase: Reliable In Vitro Culture Solutions for Your Alveolar Research

Speaker: Johanna Finn, PhD | Scientist

Location: Room 2001
Speaker Bio: Dr. Johanna Finn obtained her PhD from the University of Illinois at Chicago where she studied the role of Notch signaling in the repair of lung alveolar epithelium after injury. She is currently an R&D Scientist in the Pulmonary group at STEMCELL Technologies, developing products optimized to support culture and differentiation of lung epithelial cells.
Abstract: In vitro models for culturing human pulmonary epithelial cells have emerged as powerful tools for studying lung cell biology. This session will focus on the alveoli—the breathing units of the lung—located in the most distal portion of the airway. The alveoli are composed of a mixture of alveolar epithelial cells, stromal cells, endothelial cells, immune cells, and extracellular matrix molecules. Alveolar type 2 (AT2) cells are the stem cells of the alveolar region; they are capable of self-renewal and differentiation into alveolar type 1 cells that are involved in the process of gas exchange. Traditional two-dimensional culture techniques have proven insufficient for the long-term culture and study of AT2 cells.

Our novel and standardized PneumaCult™ Alveolar Organoid Media and protocols can be used for the expansion and differentiation of primary human tissue-derived alveolar epithelial cells. In addition, our STEMdiff™ product line includes kits for the efficient and reproducible differentiation of hPSCs into branching lung organoids and Nkx2.1+ lung progenitors. These new tools will enable researchers to focus their efforts on addressing scientific questions regarding alveolar biology and respiratory diseases, such as COVID-19 and chronic obstructive pulmonary disease, rather than on optimizing and troubleshooting reagents to ensure consistent, high-quality cultures.
11:00 a.m. - 11:45 a.m.

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Meet Up: Stem Cell Podcast - Meet the Hosts

Description: Meet the hosts of the Stem Cell Podcast, Daylon James and Arun Sharma, and learn how your research could be featured on a future episode.

Location: Meet-Up Hub, Exhibit Hall
11:30 a.m. - 12:30 p.m.

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Innovation Showcase: New Advances in Intestinal Organoid Applications: Drug Discovery and Immunotherapy

Speaker: Ryan Conder, PhD | Director, Epithelial and Organoid Systems

Location: Room 2007
Speaker Bio: Dr. Ryan Conder completed his PhD in Molecular Biology and Biochemistry at Simon Fraser University. Prior to joining STEMCELL Technologies, Ryan investigated the mechanisms regulating proliferation and differentiation of adult intestinal stem cells in the group of Dr. Jurgen Knoblich at the Institute for Molecular Biotechnology of the Austrian Academy of Sciences (IMBA). As Director of Epithelial and Organoid Systems, he oversees all research and development that supports these exciting technologies. He also holds an Adjunct Professor position in the Department of Molecular Biology and Biochemistry at Simon Fraser University.
Abstract: Intestinal organoid cultures offer greater physiological relevance than traditional cell culture platforms. As a tool for drug discovery, we have optimized the use of intestinal organoids—grown with IntestiCult™ Organoid Growth Medium—as a model for studying the response to treatment with common drugs known for intestinal toxicity. Drug responses in organoids were compared against those in Caco2 cell cultures. While some responses were similar in both models, organoids provided new insights on the responses to colchicine and gefitinib, which were not captured by Caco2 cell cultures. Furthermore, we used organoid monolayer cultures established with IntestiCult™ Organoid Differentiation Medium for barrier permeability assays, measuring both TEER and FITC-dextran permeability as readouts for barrier integrity. Organoid monolayer cultures, but not Caco2 cells, were effective at demonstrating the responses to the drugs colchicine and AZD8931. Finally, we employed a colorectal cancer (CRC) organoid model and optimized a media formulation for the maintenance of an organoid-T cell co-culture. This allowed us to treat CRC organoids with patient-matched tumor-infiltrating lymphocytes as a killing assay, providing an in vitro model for immunotherapy. Together, our data demonstrates the utility of organoids as new models for drug discovery in academic, clinical, and industrial settings.
3:00 p.m. - 4:00 p.m.

Poster: A Human Pluripotent Stem Cell-Derived Organoid Model for Recapitulation of Central Nervous System (CNS) Barrier and Fluid Secretion Functions of the Choroid Plexus

Speaker: Leon H. Chew, MSc | Senior Scientist

Details: Poster #513 | Poster Session 3
3:00 p.m. - 4:00 p.m.

Poster: An Engineered Serum- and Feeder Cell-Free System for the Efficient Generation Of CD19+ B Cells From Human Stem Cells

Speaker: Diana Golubeva, MSc | Senior Research Associate

Details: Poster #917 | Poster Session 3
3:00 p.m. - 5:00 p.m.

Drop-In: Stem Cell Podcast Recording

Description: Interested in being featured on an episode of the Stem Cell Podcast? Stop by our on-site studio to share your thoughts on the meeting and the future of stem cell research.

Location: Room 2204
4:00 p.m. - 5 :00 p.m.

Poster: Optimized Organoid Culture Media for the Long-Term Expansion and Efficient Differentiation of Alveolar Epithelial Cells

Speaker: Johanna Finn, PhD | Scientist

Details: Poster #326 | Poster Session 3


New Tools and Technologies

Explore new technologies that can help you efficiently complete your experiments and take your research further.

Be the first to know about our upcoming products >


New: PneumaCult™ Alveolar Organoid Media

Grow, expand, and differentiate organoids from human alveolar epithelial cells with an in vitro culture system that recapitulates key features of ATII and ATI cells in vivo.

Related Resource:
Try PneumaCult™


IntestiCult™ Organoid Differentiation Medium (Human)

Enjoy greater experimental flexibility and differentiate intestinal organoids in 3D, or in 2D as monolayers or ALI cultures, with this complete culture medium.

Related Webinar:
Functional Applications of Intestinal Organoids


New: HepatiCult™ Organoid Kit (Human)

Reliably generate, expand, and differentiate physiologically relevant human liver organoids from fresh or cryopreserved human liver tissue.

Related Protocol:
Establishment of 3D Organoid-Derived Hepatic Monolayers Using HepatiCult™ Organoid Initiation Medium (Human)

See More Featured Organoids Products >


New: CloneR™2

Generate hPSC lines with improved cloning efficiencies that maintain their genomic integrity and downstream differentiation potential in single-cell workflows.

Related Webinar:
Facilitating hPSC Single Cell Seeding Workflows Using CloneR™2


mTeSR™ Plus, cGMP

Gain control over your feeding schedule and achieve superior culture morphology with this stabilized feeder-free medium for human ES and iPS cells.

Related Technical Video:
How to Transition hPSCs into mTeSR™ Plus


New: PBS-MINI Bioreactor

Scale up your hPSCs with lower shear stress by using this bioreactor in combination with mTeSR 3D, TeSR-E8 3D, and TeSR AOF 3D (coming soon!).

Related Flyer:
Scale Up Flyer

See More Featured Products for Pluripotent Stem Cells >


STEMdiff™ Immune Kits

Reproducibly generate high yields of T cells, NK cells, or monocytes from hPSCs in serum-free and feeder-free culture conditions.

Related Webinar:
From hPSCs to Immune Cells: Immune Cell Generation from Human Pluripotent Stem Cells in Feeder- and Serum-Free Cultures


StemSpan™ NK Cell Generation Kit

Differentiate CD34+ hematopoietic progenitor cells to NK cells, without the use of stromal cells.

Related Technical Bulletin:
Expansion and Differentiation of Hematopoietic Stem and Progenitor Cells into Natural Killer (NK) Cells Using StemSpan™ Medium and Supplements


ImmunoCult™-XF T Cell Expansion Medium

Expand isolated human T cells in serum-free and xeno-free culture conditions.

Related Wallchart:
Wallchart: Production of CAR T Cells

See More Featured Hematopoietic, Immune & Myogenic Products >


New: STEMdiff™ Sensory Neuron Differentiation Kit

Generate functional, human-specific sensory neurons from hPSC-derived neural crest cells using this streamlined culture system.

Related Scientific Poster:
Efficient Differentiation of Human Pluripotent Stem Cells to Sensory Neurons


STEMdiff™ Midbrain Neuron Differentiation Kit

Obtain midbrain-type dopaminergic neurons from hPSC-derived neural progenitors with this defined and serum-free kit.

Related Webinar:
Modeling Neurodegenerative Diseases with STEMdiff™ Pluripotent Stem Cell-Derived Neural Culture Systems


STEMdiff™ Microglia Differentiation Kit

Differentiate hPSC-derived microglia from hematopoietic progenitor cells for modeling neuroinflammation, neurodegeneration, and co-culture applications.

Related Webinar:
Modeling Alzheimer's risk using human TREM2-knockout microglia

See More Featured Neural Products >


TeSR™-AOF, cGMP

Reduce risk and obtain greater numbers of high-quality cells in your hPSC-derived cell therapy development with this maintenance medium, manufactured under relevant cGMPs.

Related Protocol:
TeSR™-AOF Data Overview


StemSpan™-AOF, cGMP

Culture and expand human hematopoietic cells in animal origin-free conditions with this medium, manufactured under relevant cGMPs.

Related Webinar:
Engineering the Hematopoietic System to Treat Non-Hematological Disorders


CryoStor® CS10, cGMP

Protect cells during freezing, thawing, and low temperature storage with this serum- and animal component-free cryopreservation medium containing 10% dimethyl sulfoxide (DMSO).

Related Protocol:
How to Cryopreserve Human Pluripotent Stem Cells in CryoStor® CS10

See More Featured Products for Cell Therapy >



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