Modeling Host-Microbe Interactions Using Human Intestinal Organoids

A common challenge to studying host-microbe interactions is the lack of optimal in vitro culture systems to recapitulate in vivo infection. In this virtual paper presentation, Dr. Devanjali Dutta discusses her research using human intestinal and lung organoids to study Cryptosporidium infection. Cryptosporidium is a protozoan parasite, a leading cause of diarrhea, and a major cause of child mortality worldwide. Dr. Dutta describes how she—and her colleagues in the lab of Dr. Hans Clevers—infected intestinal and lung organoids derived from healthy human donors with Cryptosporidium. In their paper*, organoids are presented as a physiologically relevant in vitro model to study Cryptosporidium and other pathogenic infections.

Dr. Devanjali Dutta is a Postdoctoral researcher in the lab of Dr. Hans Clever at the Hubrecht Institute.

*Heo I, Dutta D et al. (2018) Nat Microbiol. 3(7):814–23.
Publish Date: January 14, 2019 Views: 151