“Regulation of Stem Cells in the Blood” Featuring Dr. Jennifer Trowbridge
Dr. Jennifer Trowbridge is an Associate Professor at the Jackson Laboratory and an Adjunct Professor at Tufts University. Her lab studies genetics and epigenetics in hematopoietic stem cell biology and leukemia. Their long-term goal is to identify new intervention strategies to extend the “healthspan” of HSCs by maintaining their robust regeneration capacity into older age and reducing risk of development of blood cancers.
Dr. Jennifer Trowbridge is an expert on the blood, the aging of its stem cells, and its malignancies. She runs a lab led and driven by women scientists in a natural and scientific paradise, the Jackson Laboratory in Maine.
Dr. Arun Sharma, host
Find more episodes at stemcellpodcast.com or wherever you get your podcasts.
This Episode's Stem Cell Roundup:
- Reversing Cardiotoxicity from Chemotherapy – Doxorubicin-induced cardiotoxicity in patient-derived cardiomyocytes can be reduced with retinoic acid receptor-γ agonists.
- Heart Vascularization in Infant Development – Researchers showed that the embryonic coronary plexus expands through the DLL4–NOTCH1 signaling pathway to vascularize the myocardium.
- iPSC-Derived NK Cells for Immunotherapy – Scientists used gene-edited iPSCs to derive natural killer (NK) cells that showed anti-tumor activity in vivo.
- Origins of Pancreatic Cancer – Through lineage-tracing, researchers found a link between renewal mechanisms in the exocrine pancreas and initiation of pancreatic carcinogenesis.
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