Functional Human Brain Models of Disease Featuring Dr. Sergiu Pașca
Dr. Sergiu Pașca is an Associate Professor of Psychiatry and Behavioral Sciences at Stanford University as well as the Bonnie Uytengsu and Family Director of the Stanford Brain Organogenesis Program. His team has developed methods for generating human brain organoids and uses them to study the programs underlying brain development, assembly, and dysfunction.
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This Episode's Science Round Up:
- Autophagy Regulates Stemness – Researchers have found that autophagy regulates the balance between self-renewal and differentiation of embryonic stem cells.
- Injury Induces Astrocyte Neurogenesis – When Notch signaling is blocked, astrocytes transition to a neural stem cell-like state after injury.
- Expanding the Skin by Stretching – Investigators have shown that stretching leads to skin expansion by the self-renewal of epidermal stem cells.
- Functional Neural Stem Cell Grafts After Spinal Cord Injury – Scientists successfully implanted neural stem/progenitor cell grafts directly into spinal cord injuries in mice. The grafts integrated with and mimicked the animal’s existing neural network.