Fast and Easy B Cell Isolation for More Sensitive CLL Assays
B-Cell Chronic Lymphocytic Leukemia (CLL) is the most common type of leukemia in the western world. CLL affects B cell lymphocytes, and causes malignant cells to proliferate and accumulate in the bone marrow and peripheral blood. These malignant CLL cells are distinguished from normal B lymphocytes by the expression of the CD5 surface marker in addition to CD19, CD20 and CD23. They also carry genetic abnormalities, which can differ among subtypes of CLL and among different leukemic subpopulations in the same individual.