Intestinal Organoids
The intestinal epithelium is a rapidly renewing tissue that can undergo complete cellular replacement every four to five days. These regenerative properties make the intestinal epithelium an attractive system for researchers studying epithelial regeneration, adult stem cell biology, disease modelling and cancer biology, both within and outside the context of the intestine.
Explore the resources below for information to support your intestinal research and the growth of intestinal organoids.
Organoids: Experts Talk Standardization at Nature Research Round Table
Global organoid experts gathered in London, UK to discuss the current state of the technology, protocol standardization, translation into patient care, nomenclature, and understanding what questions a given organoid culture can and can't answer.
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SnapShot: The Intestinal Crypt
Overview of the intestinal stem cell niche, major cell types and signaling pathways -
SnapShot: GI Tract Development
Overview of gastrointestinal tract specification signals and summary of pancreatic cellular hierarchy and cell markers -
SnapShot: Growing Organoids from Stem Cells
Key culture conditions and organoid-forming cells from a variety of epithelial tissues