The Mammalian Nervous System Featuring Dr. Freda Miller

Dr. Freda Miller is a Senior Scientist at the Hospital for Sick Children and Professor at the University of Toronto. Her research focuses on the cellular mechanisms that regulate development of the mammalian nervous system, with a particular interest in stem cells and trophic factors.

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This Episode's Stem Cell Roundup:

  • First Results from Major Studies of Human Genetic Variation – A massive genome-sequencing and analysis effort has produced the most comprehensive sets of data and tools for understanding human genetic variation so far.
  • Exploring Stem Cell Differentiation – Researchers have developed a new highly multiplexed single-cell RNA sequencing method to understand the signaling pathways that drive embryonic stem cell differentiation.
  • Tri-Cellular Cardiac Microtissue Model – By combining three types of cardiac cells, scientists have developed a human iPSC-derived microtissue platform for modeling multicellular cardiac diseases, and revealed non-cardiomyocyte contributions to heart disease.
  • Modeling the Early Embryonic Brain – Neural tube development has been modeled by exposing embryonic stem cells to WNT signaling gradients that mimic developmental patterning.
Publish Date: December 04, 2020

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