Hematopoietic Stem and Progenitor Cell Research
The defining properties of multipotent hematopoietic stem cells (HSCs) are their ability to differentiate into multiple lymphoid and myeloid lineages, as well as to self-renew to ensure that the HSC pool is not depleted over the lifespan of an individual. As HSCs proliferate, they progress through a series of lineage commitment steps, producing hematopoietic progenitor cells (HPCs) that are shorter-lived and more restricted in their differentiation potential.
Explore our scientific resources below to learn more about how to source, culture and analyze the biology of these important cells.
Procedure for Setting Up the CFU Assay
This video provides step-by-step guidelines for setting up hematopoietic colony-forming unit (CFU) assays using methylcellulose-based MethoCult™ medium. Steps include preparing cells, plating semi-solid medium and incubating.
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Identification of Colonies Derived from Human Hematopoietic Progenitors
Representative colony images and tips for identifying progenitor subtypes in CFU assays -
Identification of Colonies Derived from Mouse Hematopoietic Progenitors
Representative colony images and tips for identifying progenitor subtypes in CFU assays -
Small Molecules, Big Impact in Cancer Research
Overview of signaling pathways and small molecules in cancer research -
Human Hematopoietic Stem and Progenitor Cell Phenotyping
Overview of subset surface markers, frequencies and assays for analysis. -
Bone Marrow Niches and HSC Fates
This wallchart provides a detailed reference on signaling pathways in the bone marrow and how these influence HSC fate decisions. Created with Nature Reviews Immunology and Nature Reviews Molecular Cell Biology in partnership with STEMCELL Technologies. -
Mouse Hematopoietic Stem and Progenitor Cell Phenotyping
Overview of mouse HSPC subset surface markers and frequencies