Lineage-specific chimerism analysis is an important tool for monitoring the outcome of allogeneic hematopoietic cell transplantations (allo-HCT). Depending on engraftment success, the host may either achieve full donor chimerism or reach a state of mixed chimerism, in which host hematopoiesis persists alongside donor hematopoiesis in the recipient. Determination of the chimerism status in transplanted recipients can indicate the potential dynamics of disease relapse, graft-versus-host disease (GVHD), graft versus tumor (GVT) effects and other outcomes.
Below is a collection of scientific resources for your chimerism research.
This Technical Bulletin reviews the importance of lineage-specific chimerism analysis, explains the need for purity assessment, and provides guidelines for assessing purity using flow cytometry.Read More >