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SAHA

Epigenetic modifier; Inhibits HDAC1 and HDAC3

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SAHA

Epigenetic modifier; Inhibits HDAC1 and HDAC3

From: 82 USD
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Epigenetic modifier; Inhibits HDAC1 and HDAC3
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Overview

SAHA (suberoylanilide hydroxamic acid) is a potent inhibitor of class I and class II histone deacetylases (HDACs). This compound inhibits the activities of HDAC1 and HDAC3 (IC50 = 10 nM and 20 nM, respectively; Richon et al.). SAHA exhibits antiproliferative properties and can cause cell cycle arrest at G1 (Marks & Breslow).

REPROGRAMMING
· Improves reprogramming efficiency from human and mouse somatic to induced pluripotent stem cells (Huangfu et al.).

CANCER RESEARCH
· Downregulates homologous recombination and leads to apoptosis in ovarian cancer cells when used in combination with olaparib (Konstantinopoulos et al.).

· SAHA downregulates Nanog expression, which leads to proliferation inhibition in head and neck cancer stem cells (Kumar et al.).
Cell Type
Cancer Cells and Cell Lines, Pluripotent Stem Cells
Species
Human, Mouse, Non-Human Primate, Other, Rat
Application
Reprogramming
Area of Interest
Cancer, Disease Modeling, Stem Cell Biology
CAS Number
149647-78-9
Chemical Formula
C₁₄H₂₀N
Purity
≥ 98%
Pathway
Epigenetic
Target
HDAC

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
SAHA
Catalog #
73902
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
SAHA
Catalog #
73902
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

Resources and Publications

Educational Materials (3)

Cytokines, Chemokines and Growth Factors
Brochure
Cytokines, Chemokines and Growth Factors
Small Molecules, Big Impact in Pluripotent Stem Cell Research
Wallchart
Small Molecules, Big Impact in Pluripotent Stem Cell Research
Small Molecules, Big Impact in Cancer Research
Wallchart
Small Molecules, Big Impact in Cancer Research

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Quality Statement:

PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.

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